Regio- and Stereoselective Copper-Catalyzed Ring Opening of Diheterobicyclic Alkenes with Grignard Reagents

被引：2
|
作者：
Crotti, Stefano [1 ]
Di Bussolo, Valeria [1 ]
Pineschi, Mauro [1 ]
机构：
[1] Univ Pisa, Dipartimento Sci Farmaceut, I-56126 Pisa, Italy
来源：
SYNTHESIS-STUTTGART | 2012年 / 44卷 / 10期
关键词：
fused ring systems; cycloadducts; copper catalysis; Grignard reagents; regioselectivity; stereoselectivity; MESO-BICYCLIC HYDRAZINES; OXABICYCLIC ALKENES; DESYMMETRIZATION; CYCLOADDUCTS; STRATEGY;
D O I：
10.1055/s-0031-1290821
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ring opening of bicyclic hydrazines and bicyclic oxazines with organomagnesium reagents under the influence of copper catalysts allows functionalized cyclopentene and cyclohexene derivatives to be obtained. Whereas complete anti-stereoselective ring opening occurred in all cases, the regioselective outcome turned out to be highly dependent on the reaction conditions used.
引用
收藏
页码：1511 / 1514
页数：4
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