SZ-117, a Monoclonal Antibody Against Matrix Metalloproteinase-2 Inhibits Tumor Cell-mediated Angiogenesis

被引：10

作者：

Bu, Zibin

Pan, Yanyan

Shang, Bingxue

Cao, Zhifei

Zhou, Quansheng ^{[1
]}

Ruan, Changgeng

机构：

[1] Soochow Univ, Affiliated Hosp 1, Jiangsu Inst Hematol, Cyrus Tang Hematol Ctr, Suzhou 215123, Peoples R China

来源：

HYBRIDOMA | 2012年 / 31卷 / 01期

关键词：

TUBE FORMATION; METASTASIS;

D O I：

10.1089/hyb.2011.0088

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, using an in vitro tube formation model, we observed that SZ117, a monoclonal antibody against matrix metalloproteinase-2 (MMP2), attenuated a capillary-like tube structure formed by tumor endothelial cell 3B11 and human sarcoma cell MG63. In addition, gelatin zymography showed that SZ117 markedly inhibited MMP2 activity, but did not affect the capability of MMP9-mediated gelatin degradation. These data suggest that SZ117 might have an anti-tumor angiogenic effect and that angiogenic tumor cells and MMP2 may be targeted by monoclonal antibodies for novel anti-tumor angiogenic and anti-cancerous drug discovery.

引用

页码：63 / 67

页数：5

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