Mammalian PIK3C3/VPS34 The key to autophagic processing in liver and heart

被引：20
|
作者：
Jaber, Nadia [1 ]
Dou, Zhixun [1 ]
Lin, Richard Z. [2 ,4 ]
Zhang, Jianhua [3 ,5 ]
Zong, Wei-Xing [1 ]
机构：
[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA
[3] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
[4] Northport VA Med Ctr, Northport, NY USA
[5] Birmingham VA Med Ctr, Birmingham, AL USA
来源：
AUTOPHAGY | 2012年 / 8卷 / 04期
关键词：
VPS34; PIK3C3; autophagy; endocytosis; PtdIns3K; PtdIns3P; liver; heart; cancer;
D O I：
10.4161/auto.19627
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
PIK3C3/Vps34 is the class III PtdIns3K that is evolutionarily conserved from yeast to mammals. Its central role in mammalian autophagy has been suggested through the use of pharmacological inhibitors and the study of its binding partners. However, the precise role of PIK3C3 in mammals is not clear. Using mouse strains that allow tissue-specific deletion of PIK3C3, we have described an essential role of PIK3C3 in regulating autophagy, and liver and heart function.
引用
收藏
页码：707 / 708
页数：2
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