Engineered biosynthesis of natural products in heterologous hosts

被引：148

作者：

Luo, Yunzi ^{[1
,2
,3
]}

Li, Bing-Zhi ^{[1
,4
]}

Liu, Duo ^{[1
,4
]}

Zhang, Lu ^{[1
,4
]}

Chen, Yan ^{[1
,4
]}

Jia, Bin ^{[1
,4
]}

Zeng, Bo-Xuan ^{[1
,4
]}

Zhao, Huimin ^{[2
,3
]}

Yuan, Ying-Jin ^{[1
,4
]}

机构：

[1] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China

[2] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[3] Univ Illinois, Inst Genom Biol, Urbana, IL 61801 USA

[4] Tianjin Univ, SynBio Res Platform, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2015年 / 44卷 / 15期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

CHOLESTEROL-LOWERING DRUG; ERYTHROMYCIN-A PRODUCTION; SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; BETA-CAROTENE; GENE-EXPRESSION; POLYKETIDE SYNTHASE; SYNTHETIC BIOLOGY; FUNCTIONAL EXPRESSION; MEVALONATE PATHWAY;

D O I：

10.1039/c5cs00025d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

引用

页码：5265 / 5290

页数：26

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