Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging

被引：18

作者：

Imai, Hirohiko ^{[1
]}

Kimura, Atsuomi ^{[1
]}

Hori, Yuki ^{[1
]}

Iguchi, Satoshi ^{[1
]}

Kitao, Takuya ^{[1
]}

Okubo, Emi ^{[1
]}

Ito, Tsuyoshi ^{[1
]}

Matsuzaki, Toshio ^{[1
]}

Fujiwara, Hideaki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Div Hlth Sci, Dept Med Phys & Engn, Suita, Osaka 5650871, Japan

来源：

NMR IN BIOMEDICINE | 2011年 / 24卷 / 10期

基金：

日本科学技术振兴机构; 日本学术振兴会;

关键词：

hyperpolarized; 129Xe; lung MRI; pulmonary function; balanced steady-state free precession; compressed sensing; spontaneous breathing; respiratory gating; emphysema; XE-129; MRI; MOUSE LUNG; HE-3; VENTILATION; GAS; SPECTROSCOPY; EMPHYSEMA; MODEL;

D O I：

10.1002/nbm.1697

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized 129Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, 129Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：1343 / 1352

页数：10

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