Maternal resveratrol treatment during pregnancy improves adverse fetal outcomes in a rat model of severe hypoxia

被引：70

作者：

Bourque, S. L. ^{[3
,4
]}

Dolinsky, V. W. ^{[5
]}

Dyck, J. R. B. ^{[2
,3
]}

Davidge, S. T. ^{[1
,3
,4
]}

机构：

[1] Univ Alberta, Dept Obstet & Gynecol, Heritage Med Res Ctr 232, Edmonton, AB T6G 2S2, Canada

[2] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada

[3] Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB T6G 2S2, Canada

[4] Univ Alberta, Womens & Childrens Hlth Res Inst, Edmonton, AB T6G 2S2, Canada

[5] Univ Manitoba, Dept Pharmacol & Therapeut, Manitoba Inst Child Hlth, Winnipeg, MB, Canada

来源：

PLACENTA | 2012年 / 33卷 / 05期

基金：

加拿大健康研究院;

关键词：

Prenatal hypoxia; Resveratrol; Intrauterine growth restriction; INTRAUTERINE GROWTH RESTRICTION; INDUCED METABOLIC SYNDROME; ERYTHROPOIETIN LEVELS; TRANS-RESVERATROL; AMNIOTIC-FLUID; HIGH-ALTITUDE; DIET; SUSCEPTIBILITY; INCREASES; ANIMALS;

D O I：

10.1016/j.placenta.2012.01.012

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prenatal hypoxia is a common complication in pregnancy. We sought to determine whether resveratrol, a phytoalexin shown to improve health in several species, improves fetal outcomes associated with prenatal hypoxia in rats. Supplementation of maternal diets with resveratrol (4 g/kg diet) from gestational day (GD) 7 to GD21 almost completely reversed fetal demise in hypoxic (8.5% oxygen) pregnancies. We also show that resveratrol crosses the placenta, and may affect the fetus directly. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：449 / 452

页数：4

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