Synthesis and biological evaluation of fluoro-substituted cationic and neutral antibiotic NHC* silver derivatives of SBC3

被引：5

作者：

Beato, Zoe ^{[1
]}

Ryan, Brad ^{[1
]}

Mueller-Bunz, Helge ^{[1
]}

Baumann, Marcus ^{[1
]}

Tacke, Matthias ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem, Dublin 4, Ireland

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2022年 / 976卷

基金：

爱尔兰科学基金会;

关键词：

NHC-silver complexes; Antimicrobial activity; Antibacterial drug candidates; Fluorination; Continuous flow; E.coli and S.aureus; HETEROCYCLIC CARBENE COMPLEXES; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL; PREVENTION; CATALYSTS;

D O I：

10.1016/j.jorganchem.2022.122436

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two fluoro-substituted neutral carbene silver acetates and thirteen cationic dicarbene silver complexes were synthesised from the appropriate imidazolium precursors in good to very good yields using batch and flow synthesis. Six of the derivatives were characterised by XRD and showed expected structural aspects in the solid state. Most of these fifteen new silver-based antimicrobial drug candidates showed improved stability as well as comparable biological activity against E. coli and Methicillin-resistant S. aureus when compared against the lead compound 1,3-dibenzyl-4,5-diphenylimidazol-2-ylidene silver(I) acetate (SBC3). Fluoro-substitution as well as the use of dicarbene complexes have the potential to develop the field of silver-based antimicrobials further. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

引用

页数：11

共 40 条

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