Carboxypeptidase A3-A Key Component of the Protease Phenotype of Mast Cells

被引：32

作者：

Atiakshin, Dmitri ^{[1
,2
]}

Kostin, Andrey ^{[1
]}

Trotsenko, Ivan ^{[1
]}

Samoilova, Vera ^{[3
]}

Buchwalow, Igor ^{[1
,3
]}

Tiemann, Markus ^{[3
]}

机构：

[1] Peoples Friendship Univ Russia, Res & Educ Resource Ctr Immunophenotyping Digital, Miklukhomaklaya Str 6, Moscow 117198, Russia

[2] Burdenko Voronezh State Med Univ, Res Inst Expt Biol & Med, Studencheskaya Str 10, Voronezh 394036, Russia

[3] Inst Hematopathol, Fangdieckstr 75a, D-22547 Hamburg, Germany

来源：

CELLS | 2022年 / 11卷 / 03期

关键词：

mast cells; carboxypeptidase A3; secretome; granules; secretory pathways; specific tissue microenvironment; ENDOCYTIC RECYCLING COMPARTMENT; SECRETORY GRANULE PROTEASES; HUMAN T-MAST; ULTRASTRUCTURAL ANALYSIS; SERGLYCIN PROTEOGLYCAN; GENE-EXPRESSION; PROCARBOXYPEPTIDASE-A; HEPARIN PROTEOGLYCAN; CHYMASE; MOUSE;

D O I：

10.3390/cells11030570

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Carboxypeptidase A3 (CPA3) is a specific mast cell (MC) protease with variable expression. This protease is one of the preformed components of the secretome. During maturation of granules, CPA3 becomes an active enzyme with a characteristic localization determining the features of the cytological and ultrastructural phenotype of MC. CPA3 takes part in the regulation of a specific tissue microenvironment, affecting the implementation of innate immunity, the mechanisms of angiogenesis, the processes of remodeling of the extracellular matrix, etc. Characterization of CPA3 expression in MC can be used to refine the MC classification, help in a prognosis, and increase the effectiveness of targeted therapy.

引用

页数：23

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