Quantitative determination of albendazole and its main metabolites in plasma

被引:46
作者
Garcia, JJ
Bolás-Fernández, F
Torrado, JJ
机构
[1] Univ Complutense Madrid, Fac Farm, Dept Parasitol, E-28040 Madrid, Spain
[2] Univ Complutense Madrid, Fac Farm, Dept Farm & Tecnol Farmaceut, E-28040 Madrid, Spain
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 1999年 / 723卷 / 1-2期
关键词
albendazole;
D O I
10.1016/S0378-4347(98)00497-6
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Three different and complementary chromatographic methods are described for quantitative determination of albendazole (ABZ) and its two main metabolites: albendazole sulphoxide (SOABZ) and albendazole sulphone (SO(2)ABZ). ABZ, SOABZ and SO(2)ABZ can be quantified by two RP-HPLC methods with an ODS2 column and two different mobile phases. One of methanol-water (60:40) for ABZ and a second one of phosphoric acid in water-acetonitrile (80:20) for SOABZ and SO(2)ABZ. SOABZ bears an asymmetric sulphur centre. Quantitative assay of (+) SOABZ and (-) SOABZ can be performed by HPLC. A chiral AGP column and a mobile phase of sodium phosphate buffer (8 mM, pH 7.0) containing different amounts of 2-propanol between 0 to 2% were used. Pharmacokinetic characteristics of ABZ following oral administration of a liquid formulation of ABZ (12 mg/kg) in mice has been studied with these three complementary HPLC methods and the results are reported. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:265 / 271
页数:7
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