Animal models used in identifying gender-related differences

被引:20
作者
Curry, BB [1 ]
机构
[1] Charles River Labs Discovery & Dev Serv, Lab Anim Resources, Worcester, MA 01608 USA
关键词
animal models; gender difference; mice; monkey; rabbit; rat;
D O I
10.1080/109158101317097737
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
There is general agreement in the scientific community on the need to identify appropriate animal models that can be used to screen for gender-based differences. At the same time, there is a growing expectation for data from these models to mimic or be more predictive of the human experience. The species in this review will include nonhuman primates, rats, mice, rabbits, swine, hamsters, gerbils, quail, and fish. Although some of the models are unique, the gender-related differences, in most instances, may be correlated with man, due to the conservation of biological systems across species.
引用
收藏
页码:153 / 160
页数:8
相关论文
共 69 条
[1]   BIOASSAY OF CAPTAN BY ZEBRAFISH LARVAE [J].
ABEDI, ZH ;
MCKINLEY, WP .
NATURE, 1967, 216 (5122) :1321-&
[2]   TRANSGENIC MODELS OF TUMOR-DEVELOPMENT [J].
ADAMS, JM ;
CORY, S .
SCIENCE, 1991, 254 (5035) :1161-1167
[3]   EFFECT OF EMBRYONIC TREATMENT WITH ESTRADIOL OR TESTOSTERONE ON SEXUAL-DIFFERENTIATION OF THE QUAIL BRAIN - CRITICAL PERIOD AND DOSE-RESPONSE RELATIONSHIPS [J].
ADKINS, EK .
NEUROENDOCRINOLOGY, 1979, 29 (03) :178-185
[4]  
ADKINS EK, 1975, J COMP PHYSIOL PSYCH, V89, P69
[5]   Gender and risk of autoimmune diseases: Possible role of estrogenic compounds [J].
Ahmed, SA ;
Hissong, BD ;
Verthelyi, D ;
Donner, K ;
Becker, K ;
Karpuzoglu-Sahin, E .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1999, 107 :681-686
[6]   Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production [J].
Arnal, JF ;
Clamens, S ;
Pechet, C ;
NegreSalvayre, A ;
Allera, C ;
Girolami, JP ;
Salvayre, R ;
Bayard, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) :4108-4113
[7]   ANDROGEN-MEDIATED SEX-DIFFERENCES OF CARDIOVASCULAR-RESPONSES IN RATS [J].
BAKER, PJ ;
RAMEY, ER ;
RAMWELL, PW .
AMERICAN JOURNAL OF PHYSIOLOGY, 1978, 235 (02) :H242-H246
[8]   Do sex differences in the brain explain sex differences in the hormonal induction of reproductive behavior? What 25 years of research on the Japanese quail tells us [J].
Balthazart, J ;
Tlemcani, O ;
Ball, GF .
HORMONES AND BEHAVIOR, 1996, 30 (04) :627-661
[9]   Estradiol increases rat aorta endothelium-derived relaxing factor (EDRF) activity without changes in endothelial NO synthase gene expression: possible role of decreased endothelium-derived superoxide anion production [J].
Barbacanne, MA ;
Rami, J ;
Michel, JB ;
Souchard, JP ;
Philippe, M ;
Besombes, JP ;
Bayard, F ;
Arnal, JF .
CARDIOVASCULAR RESEARCH, 1999, 41 (03) :672-681
[10]   Acute effects of 17 beta-estradiol on the coronary microcirculation: observations in sedated, closed-chest domestic swine [J].
Berman, M ;
Gewirtz, H .
CORONARY ARTERY DISEASE, 1997, 8 (06) :351-361