New Targets and Targeted Drugs for the Treatment of Cancer: An Outlook to Pediatric Oncology

被引：7

作者：

Rossig, Claudia ^{[1
]}

Juergens, Heribert ^{[1
]}

Berdel, Wolfgang E. ^{[2
]}

机构：

[1] Univ Childrens Hosp Munster, Dept Pediat Hematol & Oncol, D-48149 Munster, Germany

[2] Univ Hosp Munster, Dept Med Hematol & Oncol A, Munster, Germany

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2011年 / 28卷 / 07期

关键词：

drug targets; molecularly targeted therapy; tumor stroma interactions; BRAIN-TUMOR CONSORTIUM; CELL LUNG-CANCER; PHASE-I TRIAL; JUVENILE MYELOMONOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; RECURRENT MALIGNANT GLIOMAS; RANDOMIZED CONTROLLED-TRIAL; METASTATIC BREAST-CANCER; ACUTE MYELOID-LEUKEMIA; TYROSINE KINASE;

D O I：

10.3109/08880018.2011.613094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Novel drugs and treatment modalities are urgently needed to further improve survival of children with cancer. In medical oncology, an increased understanding of the molecular basis of cancer is driving the development of new drugs that target relevant signaling pathways in cancer cells and tumor microenvironment. Small-molecule modulators of signal transduction and monoclonal antibodies against various cellular targets have been approved in adult cancers in recent years. These drugs are now starting to be considered for the use in children. Despite the biological differences between adult and pediatric cancers, common cellular pathways have emerged from experimental research. Thus, insights into clinical experience with molecular targeted drugs in adults may help to accelerate progress in pediatric oncology. Here, the authors review molecules and pathways for which drugs are approved for adult cancer treatment and provide links to existing and potential applications in pediatric oncology.

引用

页码：539 / 555

页数：17

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