Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and potential evaluation of its anticancer drug effects in an orthotopic colon carcinoma mice model

被引：60

作者：

Wang, Yan ^{[1
,2
]}

Yu, Feifei ^{[2
]}

Luo, Xianzhu ^{[1
,2
]}

Li, Mingshun ^{[1
,2
]}

Zhao, Linlu ^{[2
]}

Yu, Fabiao ^{[1
,2
]}

机构：

[1] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Peoples R China

[2] Hainan Med Univ, Coll Clin Med,Key Lab Hainan Trauma & Disaster R, Key Lab Emergency & Trauma,Coll Emergency & Traum, Minist Educ,Coll Pharm,Inst Funct Mat & Mol Imagi, Haikou 57119, Hainan, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 32期

基金：

海南省自然科学基金;

关键词：

TUMOR-TISSUE; LIVING CELLS; ACTIVATION;

D O I：

10.1039/d0cc00297f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We establish a near-infrared two-photon fluorescent probe for the detection of CE2 with high selectivity and sensitivity. This probe exhibits low cytotoxicity and superior tissue penetration ability for evaluating the real-time activity of CE2 in living cells, in cancer tissues, and in a colon carcinoma mice model.

引用

页码：4412 / 4415

页数：4

共 13 条

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