Catalytic, enantioselective synthesis of α-aminonitriles with a novel zirconium catalyst

被引：0

作者：

Ishitani, H

Komiyama, S

Kobayashi, S

机构：

[1] Univ Tokyo, Japan Sci & Technol Corp, CREST, Grad Sch Pharmaceut Sci,Bunkyo Ku, Tokyo 1130033, Japan

[2] Tokyo Univ Sci, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1620825, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1998年 / 37卷 / 22期

关键词：

amino acids; asymmetric catalysis; asymmetric synthesis; Lewis acids; zirconium;

D O I：

10.1002/(SICI)1521-3773(19981204)37:22<3186::AID-ANIE3186>3.0.CO;2-E

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Strecker reactions of aldimines with Bu3SnCN in the presence of the novel chiral zirconium binuclear catalyst 1 provide α-aminonitriles in good yields and with high enantioselectivities. The reaction can be applied to a wide range of substrates. Since both enantiomers of the choral sources are readily available, both enantiomers of the α-aminonitriles are easily prepared according to this method. L = N-methylimidazole.

引用

页码：3186 / 3188

页数：3

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