Role of Toll-like receptors in natural killer cell function in acute lymphoblastic leukemia

被引:6
作者
Gallardo-Zapata, Janet [1 ,2 ]
Maldonado-Bernal, Carmen [1 ]
机构
[1] Childrens Hosp Mexico Federico Gomez, Immunol & Prote Res Unit, 192 Calle Dr Marquez Colonia Doctores, Mexico City 06720, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico
关键词
natural killer cells; Toll-like receptors; acute lymphoblastic leukemia; cytotoxic phenotype; immunoregulatory phenotype; HUMAN NK CELLS; T-CELLS; PROGNOSTIC-SIGNIFICANCE; DENDRITIC CELLS; IFN-GAMMA; FOLLOW-UP; B-CELLS; ACTIVATION; EXPRESSION; CYTOTOXICITY;
D O I
10.3892/ol.2021.13009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Natural killer (NK) cells are specialized lymphocytes primarily involved in the response to infection and tumors. NK cells are characterized by the presence of specific surface molecules, as well as a wide repertoire of receptors that impart microenvironment-dependent effector functions. Among these receptors, Toll-like receptors (TLRs) can be activated to condition the NK response to either a cytotoxic or immunoregulatory phenotype. However, cellular function is frequently impaired during disorders such as cancer. In the last decade, it has become increasingly evident that the stimulation of NK cells is a requirement for their increased cytotoxic activity. TLR activation has been suggested as an alternative route for reestablishing the antitumor activity of NK cells. The present review summarizes the characteristics of NK cells, their receptors, the expression and function of NK cell TLRs, and their functional status in cancer, primarily acute lymphoblastic leukemia.
引用
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页数:10
相关论文
共 93 条
[1]   Natural Killer Cells: Development, Maturation, and Clinical Utilization [J].
Abel, Alex M. ;
Yang, Chao ;
Thakar, Monica S. ;
Malarkannan, Subramaniam .
FRONTIERS IN IMMUNOLOGY, 2018, 9
[2]   TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals [J].
Adib-Conquy, Minou ;
Scott-Algara, Daniel ;
Cavaillon, Jean-Marc ;
Souza-Fonseca-Guimaraes, Fernando .
IMMUNOLOGY AND CELL BIOLOGY, 2014, 92 (03) :256-262
[3]   The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules:: implications for tumor immune escape [J].
Algarra, I ;
García-Lora, A ;
Cabrera, T ;
Ruiz-Cabello, F ;
Garrido, F .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2004, 53 (10) :904-910
[4]   Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells [J].
Alter, Galit ;
Suscovich, Todd J. ;
Teigen, Nickolas ;
Meier, Angela ;
Streeck, Hendrik ;
Brander, Christian ;
Altfeld, Marcus .
JOURNAL OF IMMUNOLOGY, 2007, 178 (12) :7658-7666
[5]   Human CD56dimCD16dim Cells As an Individualized Natural Killer Cell Subset [J].
Amand, Mathieu ;
Iserentant, Gilles ;
Poli, Aurelie ;
Sleiman, Marwan ;
Fievez, Virginie ;
Pilar Sanchez, Isaura ;
Sauvageot, Nicolas ;
Michel, Tatiana ;
Aouali, Nassera ;
Janji, Bassam ;
Milena Trujillo-Vargas, Claudia ;
Seguin-Devaux, Carole ;
Zimmer, Jacques .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[6]  
[Anonymous], 2009, NATURAL KILLER CELLS
[7]   Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving bid [J].
Barry, M ;
Heibein, JA ;
Pinkoski, MJ ;
Lee, SF ;
Moyer, RW ;
Green, DR ;
Bleackley, RC .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) :3781-3794
[8]   Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2 [J].
Becker, I ;
Salaiza, N ;
Aguirre, M ;
Delgado, J ;
Carrillo-Carrasco, N ;
Kobeh, LG ;
Ruiz, A ;
Cervantes, R ;
Torres, AP ;
Cabrera, N ;
González, A ;
Maldonado, C ;
Isibasi, A .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 130 (02) :65-74
[9]   Evidence for NK cell subsets based on chemokine receptor expression [J].
Berahovich, Robert D. ;
Lai, Nu L. ;
Wei, Zheng ;
Lanier, Lewis L. ;
Schall, Thomas J. .
JOURNAL OF IMMUNOLOGY, 2006, 177 (11) :7833-7840
[10]   CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell Differentiation [J].
Beziat, Vivien ;
Duffy, Darragh ;
Stephanie Nguyen Quoc ;
Le Garff-Tavernier, Magali ;
Decocq, Julie ;
Combadiere, Behazine ;
Debre, Patrice ;
Vieillard, Vincent .
JOURNAL OF IMMUNOLOGY, 2011, 186 (12) :6753-6761