Ion Channel Trafficking: Control of Ion Channel Density as a Target for Arrhythmias?

被引：23

作者：

Balse, Elise ^{[1
]}

Boycott, Hannah E. ^{[2
]}

机构：

[1] Univ Paris 06, INSERM, UPMC Univ Paris 6,Unite Rech Malad Cardiovasc Met, UMRS 1166,Sorbonne Univ,Fac Med Pitie Salpetriere, Paris, France

[2] Univ Oxford, John Radcliffe Hosp, Dept Cardiovasc Med, Oxford, England

来源：

FRONTIERS IN PHYSIOLOGY | 2017年 / 8卷

关键词：

potassium channels; sodium channel; arrhythmias; cardiac; trafficking; accessory proteins; LONG-QT SYNDROME; ANCHORING PROTEIN SAP97; POTASSIUM CHANNEL; ATRIAL MYOCYTES; CARDIAC MYOCYTES; VENTRICULAR MYOCYTES; I-KR; INWARD RECTIFIER; PLASMA-MEMBRANE; KV1.5; CHANNELS;

D O I：

10.3389/fphys.2017.00808

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The shape of the cardiac action potential (AP) is determined by the contributions of numerous ion channels. Any dysfunction in the proper function or expression of these ion channels can result in a change in effective refractory period (ERP) and lead to arrhythmia. The processes underlying the correct targeting of ion channels to the plasma membrane are complex, and have not been fully characterized in cardiac myocytes. Emerging evidence highlights ion channel trafficking as a potential causative factor in certain acquired and inherited arrhythmias, and therapies which target trafficking as opposed to pore block are starting to receive attention. In this review we present the current evidence for the mechanisms which underlie precise control of cardiac ion channel trafficking and targeting.

引用

页数：6

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