Catalytic intermolecular ortho-arylation of phenols

被引：184

作者：

Bedford, RB ^{[1
]}

Limmert, ME ^{[1
]}

机构：

[1] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 22期

关键词：

D O I：

10.1021/jo030157k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of rhodium catalysts such as [RhCl(PPh3)(3)] or [{RhCl(COD)}(2)] with PiPr(2)(OAr) or P(NMe2)(3) co-catalysts allows the ortho-selective intermolecular arylation of phenols. The reaction proceeds via orthometalation of P-OAr groups and then transesterification liberates the product phenol. When 2-substituted phenols are used as substrates, [RhCl(PPh3)(3)]/iPr(2)(OAr) mixtures are typically the catalysts of choice, whereas for substrates without 2-substitution [{RhCl(COD)}(2)]/P(NMe2)(3) mixtures tend to give better results.

引用

页码：8669 / 8682

页数：14

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