Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster

被引：24

作者：

Aiello, Giuseppe ^{[1
]}

Sabino, Cosimo ^{[1
]}

Pernici, Davide ^{[1
]}

Audano, Matteo ^{[2
]}

Antonica, Francesco ^{[1
]}

Gianesello, Matteo ^{[1
]}

Ballabio, Claudio ^{[1
]}

Quattrone, Alessandro ^{[3
]}

Mitro, Nico ^{[2
]}

Romanel, Alessandro ^{[4
]}

Soldano, Alessia ^{[3
]}

Tiberi, Luca ^{[1
]}

机构：

[1] Univ Trento, Dept CIBIO, Armenise Harvard Lab Brain Disorders & Canc, Trento, Italy

[2] Univ Milan, Dipartimento Sci Farmacol & Biomol, DiSFeB, Milan, Italy

[3] Univ Trento, Dept CIBIO, Lab Translat Genom, Trento, Italy

[4] Univ Trento, Dept CIBIO, Lab Bioinformat & Computat Genom, Trento, Italy

来源：

EMBO REPORTS | 2022年 / 23卷 / 09期

基金：

欧盟地平线“2020”;

关键词：

aging; early-life treatment; mTOR; sulfotransferases; CYTOSOLIC SULFOTRANSFERASES; EXPRESSION ANALYSIS; GENE-EXPRESSION; FRAILTY INDEX; MODULATION; RESISTANCE; EXTENSION; PACKAGE; HEALTH; YEAST;

D O I：

10.15252/embr.202255299

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.

引用

页数：19

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