Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1-42 Oligomer-Induced Neuronal Injury

被引：26

作者：

Tan, Yuan ^{[1
]}

Ren, Huixia ^{[1
]}

Shi, Zhe ^{[1
]}

Yao, Xiaoli ^{[2
]}

He, Chengwei ^{[1
]}

Kang, Jing-X ^{[3
,4
]}

Wan, Jian-Bo ^{[1
]}

Li, Peng ^{[1
]}

Yuan, Ti-Fei ^{[5
]}

Su, Huanxing ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Natl Key Clin Dept & Key Discipline Neurol, Guangzhou 510080, Guangdong, Peoples R China

[3] Massachusetts Gen Hosp, Dept Med, Lab Lipid Med & Technol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 05期

关键词：

Alzheimer's disease; A beta oligomers; DHA; Omega-3; Fat-1; mice; N-3; FATTY-ACIDS; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; BRAIN; TRIAL; RISK; FISH; SUPPLEMENTATION; OMEGA-3-FATTY-ACIDS; PHOSPHOLIPIDS;

D O I：

10.1007/s12035-015-9224-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid has been associated with reduced risk of Alzheimer's disease (AD) in epidemiological reports. However, the underlying mechanism remains to be elucidated. Here, we report that exogenous DHA administration could protect neurons against A beta oligomer-induced injury both in vitro and in vivo, partly through reducing the endoplasmic reticulum (ER) stress, and preventing cell apoptosis. In transgenic fat-1 mice with enriched omega-3 fatty acids, A beta oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. We conclude that endogenous DHA are neuroprotective in pathogenesis processes of AD.

引用

页码：3146 / 3153

页数：8

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