1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana

被引：792

作者：

Alonso-Blanco, Carlos ^{[1
]}

Andrade, Jorge ^{[1
]}

Becker, Claude ^{[1
]}

Bemm, Felix ^{[1
]}

Bergelson, Joy ^{[1
]}

Borgwardt, Karsten M. ^{[1
]}

Cao, Jun ^{[1
]}

Chae, Eunyoung ^{[1
]}

Dezwaan, Todd M. ^{[1
]}

Ding, Wei ^{[1
]}

Ecker, Joseph R. ^{[1
]}

Exposito-Alonso, Moises ^{[1
]}

Farlow, Ashley ^{[1
]}

Fitz, Joffrey ^{[1
]}

Gan, Xiangchao ^{[1
]}

Grimm, Dominik G. ^{[1
]}

Hancock, Angela M. ^{[1
]}

Henz, Stefan R. ^{[1
]}

Holm, Svante ^{[1
]}

Horton, Matthew ^{[1
]}

Jarsulic, Mike ^{[1
]}

Kerstetter, Randall A. ^{[1
]}

Korte, Arthur ^{[1
]}

Korte, Pamela ^{[1
]}

Lanz, Christa ^{[1
]}

Lee, Cheng-Ruei ^{[1
]}

Meng, Dazhe ^{[1
]}

Michael, Todd P. ^{[1
]}

Mott, Richard ^{[1
]}

Muliyati, Ni Wayan ^{[1
]}

Nagele, Thomas ^{[1
]}

Nagler, Matthias ^{[1
]}

Nizhynska, Viktoria ^{[1
]}

Nordborg, Magnus ^{[1
]}

Novikova, Polina Yu. ^{[1
]}

Pico, F. Xavier ^{[1
]}

Platzer, Alexander ^{[1
]}

Rabanal, Fernando A. ^{[1
]}

Rodriguez, Alex ^{[1
]}

Rowan, Beth A. ^{[1
]}

Salome, Patrice A. ^{[1
]}

Schmid, Karl J. ^{[1
]}

Schmitz, Robert J. ^{[1
]}

Seren, Umit ^{[1
]}

Sperone, Felice Gianluca ^{[1
]}

Sudkamp, Mitchell ^{[1
]}

Svardal, Hannes ^{[1
]}

Tanzer, Matt M. ^{[1
]}

Todd, Donald ^{[1
]}

Volchenboum, Samuel L. ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, Spemannstr 35, D-72076 Tubingen, Germany

来源：

CELL | 2016年 / 166卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 奥地利科学基金会; 英国惠康基金;

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; GENETIC-VARIATION; FLOWERING TIME; LINKAGE DISEQUILIBRIUM; TARGET GENES; HISTORY; MODEL; ADAPTATION; DIVERSITY; ACCESSIONS;

D O I：

10.1016/j.cell.2016.05.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arabidopsis thaliana serves as a model organism for the study of fundamental physiological, cellular, and molecular processes. It has also greatly advanced our understanding of intraspecific genome variation. We present a detailed map of variation in 1,135 high-quality re-sequenced natural inbred lines representing the native Eurasian and North African range and recently colonized North America. We identify relict populations that continue to inhabit ancestral habitats, primarily in the Iberian Peninsula. They have mixed with a lineage that has spread to northern latitudes from an unknown glacial refugium and is now found in a much broader spectrum of habitats. Insights into the history of the species and the fine-scale distribution of genetic diversity provide the basis for full exploitation of A. thaliana natural variation through integration of genomes and epigenomes with molecular and non-molecular phenotypes.

引用

页码：481 / 491

页数：11

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