Synthesis of 4-acetylbenzoxazolin-2(3H)-one reported from Zea mays

被引：7

作者：

Kluge, M ^{[1
]}

Sicker, D ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期

关键词：

D O I：

10.1021/np970525d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A three-step alternative synthesis of 4-acetylbenzoxazolin-2(3H)-one (4) is reported. Starting from inexpensive 3-hydroxyacetophenone (1) 3-hydroxy-2-nitroacetophenone (2) is prepared by nitration followed by catalytic hydrogenation to yield 2-amino-3-hydroxyacetophenone (3) in which a C=O unit is inserted by means of bis(trichloromethyl)carbonate (triphosgene) in the presence of triethylamine to afford 4 in 35% overall yield.

引用

页码：821 / 822

页数：2

共 8 条

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