Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation

被引:21
作者
Kuklinski, Lawrence F. [1 ]
Li, Shufeng [2 ]
Karagas, Margaret R. [4 ]
Weng, Wen-Kai [2 ,3 ]
Kwong, Bernice Y. [2 ]
机构
[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Dermatol, 780 Welch Rd,CJ220, Palo Alto, CA 94304 USA
[3] Stanford Univ, Dept Med Blood & Marrow Transplantat, Sch Med, Stanford, CA 94305 USA
[4] Dartmouth Hitchcock Med Ctr, Dept Epidemiol, Hanover, NH USA
基金
美国国家卫生研究院;
关键词
basal cell carcinoma; bone marrow transplantation; hematopoietic cell transplantation; nonmelanoma skin cancer; squamous cell carcinoma; voriconazole; CARCINOMA; LUNG; RECIPIENTS; EXPOSURE; IMPACT; KERATINOCYTES; PROPHYLAXIS; ULTRAVIOLET; DISEASE; AGENTS;
D O I
10.1016/j.jaad.2017.06.032
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT). Objective: We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT. Methods: In all, 1220 individuals who had undergone allogeneic HCT and 1418 who had undergone autologous HCT were included in a retrospective cohort study. Multivariate analysis included voriconazole exposure and other known risk factors for NMSC. Results: In multivariate analysis, voriconazole use increased the risk for NMSC (hazard ratio, 1.82; 95% confidence interval, 1.13-2.91) among those who had undergone allogeneic HCT, particularly for SCC (hazard ratio, 2.25; 95% confidence interval, 1.30-3.89). Voriconazole use did not appear to confer increased risk for NMSC among those who had undergone autologous HCT. Limitations: This is a retrospective study. Conclusion: Voriconazole use represents an independent factor that may contribute to increased risk specifically for SCC in the allogeneic HCT population.
引用
收藏
页码:706 / 712
页数:7
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