Cytotoxicity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line

被引：8

作者：

Fukushima, M

Fukamiya, N ^{[1
]}

Okano, M

Nehira, T

Tagahara, K

Zhang, SX

Zhang, DC

Tachibana, Y

Bastow, KF

Lee, KH

机构：

[1] Hiroshima Univ, Fac Integrated Arts & Sci, Dept Interdisciplinary Studies Nat Environm, Higashihiroshima 7398521, Japan

[2] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6588558, Japan

[3] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[4] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

CANCER LETTERS | 2000年 / 158卷 / 02期

关键词：

cytotoxicity; non-alkaloid type taxane diterpene; beta-Tublin mutant tumor cell line;

D O I：

10.1016/S0304-3835(00)00506-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Seven taxane diterpenes were isolated from the EtOH extract of the aerial parts of Taxus chinensis. and evaluated for cytotoxicity against nine human cell lines, including a beta -tublin mutant resistant to paclitaxel. Compound 2 a non-alkaloid-type taxane diterpene, showed significant cytotoxicity in most cell lines, and notably, equipotent against both parental and beta -tubiin mutant tumor cell lines. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

共 4 条

[1] Multidrug resistant cancer cells susceptibility to cytotoxic taxane Diterpenes from Taxus yunnanensis and Taxus chinensis
Shinozaki, Y
Fukamiya, N
Uchiyama, C
Okano, M
Tagahara, K
Bastow, KF
Lee, KH
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (19) : 2785 - 2788
[2] Lathyrane and Jatrophane Diterpenoids from Euphorbia helioscopia Evaluated for Cytotoxicity against a Paclitaxel-Resistant A549 Human Lung Cancer Cell Line
Zhou, Di
Zhang, Fengjiao
Kikuchi, Takashi
Yao, Miao
Otsuki, Kouharu
Chen, Gang
Li, Wei
Li, Ning
JOURNAL OF NATURAL PRODUCTS, 2022, 85 (04): : 1174 - 1179
[3] Establishment and characterization of a paclitaxel-resistant human non-small cell lung cancer cell line
Chu, JJ
Chiang, CD
Rao, CS
Chang, WM
Lai, YK
ANTICANCER RESEARCH, 2000, 20 (04) : 2449 - 2456
[4] Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer
Ding, Yahui
Wang, Tianpeng
Chen, Tianyang
Xie, Chunfeng
Zhang, Quan
BIOORGANIC CHEMISTRY, 2020, 101

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