Self-Assemblies of Triskelion A2B-Type Amphiphilic Polypeptide Showing pH-Responsive Morphology Transformation

被引：13
|
作者：
Uesaka, Akihiro [1 ]
Ueda, Motoki [1 ]
Makino, Akira [1 ]
Imai, Tomoya [2 ]
Sugiyama, Junji [2 ]
Kimura, Shunsaku [1 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Dept Chem Mat, Nishikyo Ku, Kyoto 6158510, Japan
[2] Kyoto Univ, Res Inst Sustainable Humanosphere RISH, Kyoto 6110011, Japan
来源：
LANGMUIR | 2012年 / 28卷 / 14期
基金：
日本科学技术振兴机构;
关键词：
RATIONAL DESIGN; HELICAL PEPTIDE; VESICLES; NANOREACTORS; NANOTUBES; DRUGS;
D O I：
10.1021/la3004867
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A pH-responsive rolled-sheet morphology was prepared from a triskelion A(2)B-type amphiphilic polypeptide having a histidine residue as a pH-responsive unit. The dimensions of the rolled sheet were 85 nm diameter and 210 nm length with a sheet turn number of 2.0 at pH 7.4. Upon decreasing the pH from 7.4 to 5.0, the layer spacing of the rolled sheets was widened from ca. 9 to ca. 19 nm due to electrostatic repulsion caused by histidine protonation. This morphology change occurred reversibly with a pH change between 7.4 and 5.0. The molecular packing in the rolled sheets was shown to be loosened at pH 5.0 on the basis of electron diffraction measurements. The tightness of the rolled sheets was thus controlled reversibly by a pH change due to a single protonation in the amphiphilic polypeptide.
引用
收藏
页码：6006 / 6012
页数：7
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