Updates on pathogen inactivation of plasma using Theraflex methylene blue system

被引：50

作者：

Seghatchian, Jerard ^{[1
]}

Walker, Wolfram H. ^{[2
]}

Reichenberg, Stefan ^{[2
]}

机构：

[1] Blood Components Technol & Hiemostasis Thrombosis, London NW3 3AA, England

[2] Maco Pharma Int GmbH, Langen, Germany

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2008年 / 38卷 / 03期

关键词：

D O I：

10.1016/j.transci.2008.04.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methylene blue (MB) treated plasma has been in clinical use for 15 years. The current Theraflex MB-Plasma system has a number of improved features compared with the original Springe methodology. This article gives an overview of processing methodology and recent developments, pathogen inactivation capacity, pharmacokinetics and toxicology, effects on plasma proteins and storage stability, clinical experience and future perspectives. Emphasises will be placed on most recent literature and updated information available. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：271 / 280

页数：10

共 46 条

[1] Phenothiazines and prion diseases: a potential mechanism of action towards oxidative stress [J].

Achour, A .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 20 (04) :305-306

[2] Protecting the blood supply from emerging pathogens: The role of pathogen inactivation [J].

Allain, JP ;

Bianco, C ;

Blajchman, MA ;

Brecher, ME ;

Busch, M ;

Leiby, D ;

Lin, L ;

Stramer, S .

TRANSFUSION MEDICINE REVIEWS, 2005, 19 (02) :110-126

[3] Methylene blue-photoinactivated plasma vs. fresh-frozen plasma as replacement fluid for plasma exchange in thrombotic thrombocytopenic purpura [J].

Alvarez-Larrán, A ;

Del Río, J ;

Ramírez, C ;

Albo, C ;

Peña, F ;

Campos, A ;

Cid, J ;

Muncunill, J ;

Sastre, JL ;

Sanz, C ;

Pereira, A .

VOX SANGUINIS, 2004, 86 (04) :246-251

[4] Phenothiazines: potential management of Creutzfeldt-Jacob disease and its variants [J].

Amaral, L ;

Kristiansen, JE .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 18 (05) :411-417

[5] Transfusing methylene blue-photoinactivated plasma instead of FFP is associated with an increased demand for plasma and cryoprecipitate [J].

Atance, R ;

Pereira, A ;

Ramírez, B .

TRANSFUSION, 2001, 41 (12) :1548-1552

[6] Factor VIII von Willebrand factor complex in methylene blue-treated fresh plasma [J].

Aznar, JA ;

Molina, R ;

Montoro, JM .

TRANSFUSION, 1999, 39 (07) :748-750

[7] TARGET STRUCTURES FOR HIV-1 INACTIVATION BY METHYLENE-BLUE AND LIGHT [J].

BACHMANN, B ;

KNUVERHOPF, J ;

LAMBRECHT, B ;

MOHR, H .

JOURNAL OF MEDICAL VIROLOGY, 1995, 47 (02) :172-178

[8]

Bopp MKF, 2001, TRANSFUSION MED, V11, P149

[9]

Cardigan R., 2002, Vox Sanguinis, V83, P190

[10] Levels of von Willebrand factor-cleaving protease are normal in methylene blue-treated fresh-frozen plasma [J].

Cardigan, R ;

Allford, S ;

Williamson, L .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 117 (01) :253-254

← 1 2 3 4 5 →