Direct Amidation of Alcohols with N-Substituted Formamides under Transition-Metal-Free Conditions

被引：144

作者：

Xu, Kun ^{[1
,2
]}

Hu, Yanbin ^{[1
,2
]}

Zhang, Sheng ^{[1
,2
]}

Zha, Zhenggen ^{[1
,2
]}

Wang, Zhiyong ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 32期

关键词：

alcohols; amides; dimethylformamide; radical reactions; transition-metal-free reactions; MONOXIDE-FREE AMINOCARBONYLATION; DIRECT AMIDE SYNTHESIS; CATALYZED CONVERSION; OXIDATIVE AMIDATION; AMBIENT CONDITIONS; BOND FORMATION; ARYL HALIDES; TRANSFER HYDROAMINATION; DIRECT CARBAMOYLATION; PRIMARY CARBOXAMIDES;

D O I：

10.1002/chem.201201203

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Go tandem! The first example of the direct amidation of alcohols with N-substituted formamides has been developed. A series of tertiary amides, including the challenging N,N-dimethyl-substituted amides, were obtained in moderate to good yields under transition-metal-free conditions (see scheme). TBHP=tert-butyl hydroperoxide. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9793 / 9797

页数：5

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