Direct Amidation of Alcohols with N-Substituted Formamides under Transition-Metal-Free Conditions

被引：143
作者：
Xu, Kun [1 ,2 ]
Hu, Yanbin [1 ,2 ]
Zhang, Sheng [1 ,2 ]
Zha, Zhenggen [1 ,2 ]
Wang, Zhiyong [1 ,2 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China
[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 32期
关键词：
alcohols; amides; dimethylformamide; radical reactions; transition-metal-free reactions; MONOXIDE-FREE AMINOCARBONYLATION; DIRECT AMIDE SYNTHESIS; CATALYZED CONVERSION; OXIDATIVE AMIDATION; AMBIENT CONDITIONS; BOND FORMATION; ARYL HALIDES; TRANSFER HYDROAMINATION; DIRECT CARBAMOYLATION; PRIMARY CARBOXAMIDES;
D O I：
10.1002/chem.201201203
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Go tandem! The first example of the direct amidation of alcohols with N-substituted formamides has been developed. A series of tertiary amides, including the challenging N,N-dimethyl-substituted amides, were obtained in moderate to good yields under transition-metal-free conditions (see scheme). TBHP=tert-butyl hydroperoxide. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9793 / 9797
页数：5
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