Long-Term Evaluation of Combination Treatment of Single Agent HD-MTX Chemotherapy up to Three Cycles and Moderate Dose Whole Brain Irradiation for Primary CNS Lymphoma

被引：6
作者：
Kobayashi, Hiroyuki [1 ]
Yamaguchi, Shigeru [1 ]
Motegi, Hiroaki [1 ]
Kaneko, Sadahiro [1 ]
Endou, Shogo [1 ]
Onimaru, Rikiya [2 ]
Terasaka, Shunsuke [1 ]
Houkin, Kiyohiro [2 ]
机构：
[1] Hokkaido Univ, Dept Neurosurg, Fac Med, Sapporo, Hokkaido, Japan
[2] Hokkaido Univ, Dept Radiat Med, Fac Med, Sapporo, Hokkaido, Japan
来源：
JOURNAL OF CHEMOTHERAPY | 2019年 / 31卷 / 01期
关键词：
Primary CNS lymphoma; High-dose chemotherapy; Methotrexate; Survival; NERVOUS-SYSTEM LYMPHOMA; INTERNATIONAL EXTRANODAL LYMPHOMA; QUALITY-OF-LIFE; COGNITIVE FUNCTIONS; METHOTREXATE; RADIOTHERAPY; THERAPY; CHEMOIMMUNOTHERAPY; RANDOMIZATION; CYTARABINE;
D O I：
10.1080/1120009X.2018.1546984
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-dose methotrexate (HD-MTX)-based chemotherapy in combination with whole brain radiotherapy (WBRT) has been a common therapy for primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the survival benefit of a minimized cycle of HD-MTX monotherapy prior to WBRT. A maximum of three cycles of HD-MTX was combined with a WBRT dose of 30 Gy and an additional localized boost was administered where remnant was observed. A total of 54 patients with newly diagnosed PCNSL were enrolled in this study. The objective response rate for HD-MTX was 80% and the median overall survival was 58.4 months. Responders to HD-MTX demonstrated better survival than patients with resistance. The concentration of MTX in serum and cerebrospinal fluid was not related the chemotherapeutic response. This study demonstrated the efficacy of HD-MTX prior to WBRT and indicated that three cycles of HD-MTX monotherapy may be sufficient in combination with radiotherapy.
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收藏
页码：35 / 41
页数：7
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