The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis

被引：150
作者：
Imamura, Takeshi [1 ,2 ]
Hikita, Atsuhiko [1 ,2 ]
Inoue, Yasumichi [3 ]
机构：
[1] Ehime Univ, Dept Mol Med Pathogenesis, Grad Sch Med, Toon, Ehime 7910295, Japan
[2] Japan Sci & Technol Agcy JST, Toon, Ehime 7910295, Japan
[3] Nagoya City Univ, Dept Drug Metab & Disposit, Grad Sch Pharmaceut Sci, Nagoya, Aichi 4678603, Japan
来源：
BREAST CANCER | 2012年 / 19卷 / 02期
关键词：
TGF-beta; Breast cancer; Metastasis; Cancer stem cell; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITIONS; RECEPTOR KINASE INHIBITOR; HORMONE-RELATED PROTEIN; TRANSCRIPTION FACTOR; CELL PLASTICITY; BONE METASTASIS; SMAD PROTEINS; IN-VIVO; C-MYC;
D O I：
10.1007/s12282-011-0321-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-beta (TGF-beta) ligand is a multifunctional growth factor that regulates various cell behavior, such as cell proliferation, differentiation, migration, and apoptosis. Because TGF-beta is a potent growth inhibitor, abnormalities in TGF-beta signaling result in carcinogenesis. In addition to tumor suppressor function, TGF-beta acts as an oncogenic factor. In particular, TGF-beta signaling plays an important role during metastasis of breast cancer. Recently, epithelial-mesenchymal transition (EMT) has been shown to confer malignant properties such as cell motility and invasiveness to cancer cells and plays crucial roles during cancer metastasis. Moreover, breast stem-like cells exhibit EMT properties. Because TGF-beta is a potent regulator of EMT as well as cell stemness, TGF-beta signaling might play a crucial role in the regulation of breast cancer stem cells.
引用
收藏
页码：118 / 124
页数：7
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