Behavioural and neurochemical effects of phosphatidylserine in MPTP lesion of the substantia nigra of rats

被引：41
作者：
Perry, JC
Da Cunha, C
Anselmo-Franci, J
Andreatini, R
Miyoshi, E
Tufik, S
Vital, MABF
机构：
[1] Univ Fed Parana, Dept Farmacol, Setor Ciencias Biol, BR-81531990 Curitiba, Parana, Brazil
[2] State Univ Sao Paulo, Fac Odontol, Dept Physiol, Sao Paulo, Brazil
[3] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 484卷 / 2-3期
基金：
巴西圣保罗研究基金会;
关键词：
phosphatidylserine; MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine); memory; (Rat); Parkinson's disease; dopamine;
D O I：
10.1016/j.ejphar.2003.11.029
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study investigated the effects of intranigral MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) infusion on rats treated with phosphatidylserine and evaluated in two memory tasks and on striatal dopamine levels. The results indicated that MPTP produced a significant decrease in the avoidance number in comparison to sham-operated and non-operated rats submitted to a two-way avoidance task. MPTP-lesioned rats exhibited an increase in the latencies to find the platform in cued version of the water maze in comparison to sham-operated and non-operated animals. The tested toxin reduced striatal dopamine levels in comparison to sham-operated and non-operated groups. A final surprising result was that phosphatidylserine was unable to reverse the cognitive deficits produced by MPTP or the reduction of striatal dopamine levels. In conclusion, the data suggest that MPTP is a good model to study the early impairment associated with Parkinson's disease and phosphatidylserine did not improve the memory impairment induced by MPTP. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：225 / 233
页数：9
相关论文
共 55 条
[1]   Phosphatidylserine reverses reserpine-induced amnesia [J].
Alves, CSD ;
Aldreatini, R ;
da Cunha, C ;
Tufik, S ;
Vital, MABF .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 404 (1-2) :161-167
[2]   CHRONIC ADMINISTRATION OF PHOSPHATIDYLSERINE DURING ONTOGENY ENHANCES SUBJECT-ENVIRONMENT INTERACTIONS AND RADIAL MAZE PERFORMANCE IN C57BL/6 MICE [J].
AMMASSARITEULE, M ;
FAGIOLI, S ;
MARITATI, M ;
POPULIN, R ;
PAVONE, F .
PHYSIOLOGY & BEHAVIOR, 1990, 47 (04) :755-760
[3]   Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse [J].
Araki, T ;
Mikami, T ;
Tanji, H ;
Matsubara, M ;
Imai, Y ;
Mizugaki, M ;
Itoyama, Y .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 12 (03) :231-238
[4]  
BIRKMAYER W, 1985, PARKINSON KRANKHEIT, P60
[5]   Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: Comparison of bovine cortex PS with egg PS and soybean PS [J].
Blokland, A ;
Honig, W ;
Brouns, F ;
Jolles, J .
NUTRITION, 1999, 15 (10) :778-783
[6]  
BRECKENRIDGE WC, 1972, BIOCHIM BIOPHYS ACTA, V266, P695, DOI 10.1016/0006-3002(72)90012-1
[7]   HOW COMMON IS DEMENTIA IN PARKINSONS-DISEASE [J].
BROWN, RG ;
MARSDEN, CD .
LANCET, 1984, 2 (8414) :1262-1265
[8]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[9]   Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia [J].
Claro, FT ;
Silva, RH ;
Frussa, R .
PHYSIOLOGY & BEHAVIOR, 1999, 67 (04) :551-554
[10]   EFFECTS OF PHOSPHATIDYLSERINE IN AGE-ASSOCIATED MEMORY IMPAIRMENT [J].
CROOK, TH ;
TINKLENBERG, J ;
YESAVAGE, J ;
PETRIE, W ;
NUNZI, MG ;
MASSARI, DC .
NEUROLOGY, 1991, 41 (05) :644-649
123456