A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis

被引:98
作者
Pacella, Claudio Maurizio [1 ]
Mauri, Giovanni [2 ]
Cesareo, Roberto [3 ]
Paqualini, Valerio [3 ]
Cianni, Roberto [3 ]
De Feo, Pierpaolo [4 ]
Gambelunghe, Giovanni [4 ]
Raggiunti, Bruno [5 ]
Tina, Doris [5 ]
Deandrea, Maurilio [6 ]
Limone, Pier Paolo [6 ]
Mormile, Alberto [6 ]
Giusti, Massimo [7 ]
Oddo, Silvia [7 ]
Achille, Gaetano [8 ]
Di Stasio, Enrico [9 ]
Misischi, Irene [10 ]
Papini, Enrico [10 ]
机构
[1] Regina Apostolorum Hosp, Dept Diagnost Imaging, Albano Laziale, Italy
[2] European Inst Oncol, Dept Intervent Radiol, Via Ripamonti 435, I-20141 Milan, Italy
[3] SM Goretti Hosp, Thyroid Dis Ctr, Latina, Italy
[4] Univ Perugia, Dept Internal Med, Perugia, Italy
[5] Atri Hosp, Endocrinol Unit, Atri, Italy
[6] A Costa Mauriziano Hosp, Thyroid Dis Ctr, Turin, Italy
[7] AOU IST IRCSS San Martino Univ Genoa, Dept Endocrinol, Genoa, Italy
[8] Inst Oncol Bari, Cerv Facial Ultrasound Diagnost & Intervent Unit, Bari, Italy
[9] Rome Catholic Univ Sacro Cuore, Inst Biochem & Clin Biochem, Rome, Italy
[10] Regina Apostolorum Hosp, Dept Endocrinol, Albano Laziale, Italy
关键词
Benign thyroid nodule; percutaneous thermal ablation; minimally invasive treatments; laser ablation; radiofrequency ablation; ASSOCIAZIONE MEDICI ENDOCRINOLOGI; PERCUTANEOUS MICROWAVE ABLATION; IMAGING FOLLOW-UP; HEPATOCELLULAR-CARCINOMA; CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION; EFFICACY; PHOTOCOAGULATION; SAFETY; CYTOPATHOLOGY;
D O I
10.1080/02656736.2017.1332395
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules.Materials and methods: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 5714years) with LA and 152 (107 females, age 5714years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12months and complications were evaluated.Results: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12months was -67 +/- 19% vs. -57 +/- 21% (p<0.001)-70 +/- 19% vs. -62 +/- 22% (p =0.001) in LA group and in RFA group, respectively. Nodules with volume>30mL had significantly higher percentage volume reduction at 6 and 12months (-69 +/- 19 vs. -50 +/- 21, p=0.001) and (-73 +/- 18 vs. -54 +/- 23 8, p=0.001) in the LA group than in the RFA group, respectively. In both groups, operator's skills affected the results. Major complications occurred in 4 cases in each group (p=0.116)Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator's skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
引用
收藏
页码:911 / 919
页数:9
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