Neurofilaments contribution in clinic: state of the art

被引：27

作者：

Delaby, Constance ^{[1
,2
]}

Bousiges, Olivier ^{[3
,4
]}

Bouvier, Damien ^{[5
]}

Fillee, Catherine ^{[6
]}

Fourier, Anthony ^{[7
]}

Mondesert, Etienne ^{[1
]}

Nezry, Nicolas ^{[8
]}

Omar, Souheil ^{[9
]}

Quadrio, Isabelle ^{[7
]}

Rucheton, Benoit ^{[10
]}

Schraen-Maschke, Susanna ^{[8
]}

van Pesch, Vincent ^{[11
]}

Vicca, Stephanie ^{[12
]}

Lehmann, Sylvain ^{[1
]}

Bedel, Aurelie ^{[13
]}

机构：

[1] Univ Montpellier, Lab Biochim Proteom Clin, CHU Montpellier, IRMB,INM,INSERM, Montpellier, France

[2] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit, Barcelona, Spain

[3] CHU Strasbourg, Lab Biochim & Biol Mol LBBM, Pole Biol Hop Hautepierre, CNRS,Lab ICube,UMR 7357, Strasbourg, France

[4] FMTS Federat Med Translat Strasbourg, Equipe IMIS, Strasbourg, France

[5] CHU Clermont Ferrand, Serv Biochim & Genet Mol, Clermont Ferrand, France

[6] Clin Univ St Luc UCLouvain, Serv Biochim Medicate, Brussels, Belgium

[7] Grp Hosp Est Lyon, Unite Diagnost Pathol Degenerat, Biochim & Biol Mol LBMMS, Ctr Biol & Pathol Est, Lyon, France

[8] Univ Lille, Lille Neurosci & Cognit, CHU Lille, UMR S U1172,LiCEND,INSERM,LabEx DISTALZ, Lille, France

[9] Inst Neurol Tunis, Lab Biol Med, Tunis, Tunisia

[10] Inst Bergonie, Lab Biol, Bordeaux, France

[11] Clin Univ St Luc UCLouvain, Serv Neurol, Brussels, Belgium

[12] Univ Paris, Hop Necker Enfants Malad, AP HP Ctr, DMU BioPhyGen,Lab Biochim Gen, Paris, France

[13] CHU Pellegrin, Serv Biochim, Bordeaux, France

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷

关键词：

neurofilament; biomarkers; neurological and neurodegenerative diseases; cut-off; biological fluids; AMYOTROPHIC-LATERAL-SCLEROSIS; LIGHT-CHAIN LEVELS; TRAUMATIC BRAIN-INJURY; MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; DIFFERENTIAL-DIAGNOSIS; BLOOD; BIOMARKER; SERUM;

D O I：

10.3389/fnagi.2022.1034684

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Neurological biomarkers are particularly valuable to clinicians as they can be used for diagnosis, prognosis, or response to treatment. This field of neurology has evolved considerably in recent years with the improvement of analytical methods, allowing the detection of biomarkers not only in cerebrospinal fluid (CSF) but also in less invasive fluids like blood. These advances greatly facilitate the repeated quantification of biomarkers, including at asymptomatic stages of the disease. Among the various informative biomarkers of neurological disorders, neurofilaments (NfL) have proven to be of particular interest in many contexts, such as neurodegenerative diseases, traumatic brain injury, multiple sclerosis, stroke, and cancer. Here we discuss these different pathologies and the potential value of NfL assay in the management of these patients, both for diagnosis and prognosis. We also describe the added value of NfL compared to other biomarkers currently used to monitor the diseases described in this review.

引用

页数：19

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