Heterogeneity of Large Cell Carcinoma of the Lung An Immunophenotypic and miRNA-Based Analysis

被引：39

作者：

Barbareschi, Mattia ^{[1
,2
]}

Cantaloni, Chiara ^{[2
]}

Del Vescovo, Valerio ^{[4
]}

Cavazza, Alberto ^{[5
]}

Monica, Valentina ^{[6
,7
]}

Carella, Rodolfo ^{[8
]}

Rossi, Giulio ^{[9
]}

Morelli, Luca

Cucino, Alberto

Silvestri, Massimo ^{[3
]}

Tirone, Giuseppe ^{[3
]}

Pelosi, Giuseppe ^{[10
]}

Graziano, Paolo ^{[11
]}

Papotti, Mauro ^{[6
,7
]}

Dalla Palma, Paolo

Doglioni, Claudio ^{[12
]}

Denti, Michela Alessandra ^{[4
]}

机构：

[1] Santa Chiara Hosp, Lab Mol Pathol, Unit Surg Pathol, I-38122 Trento, Italy

[2] Santa Chiara Hosp, Trentino Biobank, Unit Surg Pathol, I-38122 Trento, Italy

[3] Santa Chiara Hosp, Surg Unit, I-38122 Trento, Italy

[4] Univ Trento, Ctr Integrat Biol, Trento, Italy

[5] Arcispedale S Maria Nuova, Unit Pathol Anat, Reggio Emilia, Italy

[6] San Luigi Hosp, Unit Pathol Anat, Orbassano, Italy

[7] Univ Turin, Orbassano, Italy

[8] S Maurizio Hosp, Unit Surg Pathol, Bolzano, Italy

[9] Azienda Osped Univ Policlin, Sect Pathol Anat, Modena, Italy

[10] Fdn IRCCS Ist Nazl Tumori, Unit Pathol & Lab Med, Milan, Italy

[11] Forlanini Hosp, Anat Pathol Unit, Rome, Italy

[12] S Raffaele Hosp, Unit Surg Pathol, Milan, Italy

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2011年 / 136卷 / 05期

关键词：

Heterogeneity; Large cell carcinoma; Lung neoplasms; miRNA; Immunophenotype; Adenocarcinoma; Squamous cell carcinoma; TRANSCRIPTION FACTOR-I; NONSMALL CELL; EXPRESSION; P63; MARKER; CANCER; TTF-1; ADENOCARCINOMAS; TUMORS; SUBCLASSIFICATION;

D O I：

10.1309/AJCPYY79XAGRAYCJ

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Large cell carcinomas (LCCs) of the lung are heterogeneous and may be of different cell lineages. We analyzed 56 surgically resected lung tumors classified as LCC on the basis of pure morphologic grounds, using a panel of immunophenotypic markers (adenocarcinoma [ADC]-specific, thyroid transcription factor-1, cytokeratin 7, and napsin A; squamous cell carcinoma [SQCC]-specific, p63, cytokeratin 5, desmocollin 3, and Delta np63) and the quantitative analysis of microRNA-205 (microRNA sample score [mRSS]). Based on immunoprofiles 19 (34%) of the cases were reclassified as ADC and 14 (25%) as SQCC; 23 (41%) of the cases were unclassifiable. Of these 23 cases, 18 were classified as ADC and 5 as SQCC according to the mRSS. Our data show that an extended panel of immunohistochemical markers can reclassify around 60% of LCCs as ADC or SQCC. However, a relevant percentage of LCCs may escape convincing immunohistochemical classification, and mRSS could be used for further typing, but its clinical relevance needs flirt her confirmation.

引用

页码：773 / 782

页数：10

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