Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis

被引：8

作者：

Vliora, Maria ^{[1
,2
]}

Nintou, Eleni ^{[1
]}

Karligiotou, Eleni ^{[1
]}

Ioannou, Leonidas G. ^{[1
]}

Grillo, Elisabetta ^{[2
]}

Mitola, Stefania ^{[2
]}

Flouris, Andreas D. ^{[1
]}

机构：

[1] Univ Thessaly, Dept Phys Educ & Sport Sci, FAME Lab, Trikala 42100, Greece

[2] Univ Brescia, Dept Mol & Translat Med, I-25121 Brescia, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 17期

关键词：

irisin; cancers; physical exercise; thermogenesis; CELL-PROLIFERATION; MOLECULAR-MECHANISMS; PANCREATIC-CANCER; MYOKINE IRISIN; EXERCISE; BREAST; EXPRESSION; INVASION; PREVENTION; MIGRATION;

D O I：

10.3390/ijms23179971

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer is a set of diseases characterized by several hallmark properties, such as increased angiogenesis, proliferation, invasion, and metastasis. The increased angiogenic activity constantly supplies the tumors with nutrients and a plethora of cytokines to ensure cell survival. Along these cytokines is a newly discovered protein, called irisin, which is released into the circulation after physical exercise. Irisin is the product of fibronectin type III domain-containing protein 5 (FNDC5) proteolytic cleavage. Recently it has been the topic of investigation in several types of cancer. In this study, we conducted a systematic review and meta-analysis to investigate its implication in different types of cancer. Our results suggest that irisin expression is decreased in cancer patients, thus it can be used as a valid biomarker for the diagnosis of several types of cancer. In addition, our results indicate that irisin may have an important role in tumor progression and metastasis since it is involved in multiple signaling pathways that promote cell proliferation and migration.

引用

页数：15

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