High-Level Quinolone-Resistant Haemophilus haemolyticus in Pediatric Patient with No History of Quinolone Exposure

被引：7

作者：

Tanaka, Emi ^{[1
,2
]}

Hirai, Yuji ^{[3
]}

Wajima, Takeaki ^{[1
,2
]}

Ishida, Yu ^{[3
]}

Kawamura, Yoshiaki ^{[4
]}

Nakaminami, Hidemasa ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Tokyo, Japan

[2] Meijo Univ, Nagoya, Aichi, Japan

[3] Tokyo Med Univ, Hachi Med Ctr, Tokyo, Japan

[4] Aichi Gakuin Univ, Nagoya, Aichi, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 01期

关键词：

INFLUENZAE STRAINS; FLUOROQUINOLONE RESISTANCE; MOLECULAR CHARACTERIZATION; JAPANESE ASSOCIATION; INFECTIOUS-DISEASES; IDENTIFICATION; GENE; SUSCEPTIBILITY; CHEMOTHERAPY; COMMITTEE;

D O I：

10.3201/eid2801.210248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of antimicrobial resistance among Haemophilus spp. is a critical concern, but high-level quinolone-resistant strains had not been isolated from children. We isolated high-level quinolone-resistant H. haemolyticus from the suction sputum of a 9-year-old patient. The patient had received home medical care with mechanical ventilation for 2 years and had not been exposed to any quinolones for >= 3 years. The H. haemolyticus strain we isolated, 2019-19, shared biochemical features with H. influenzae. However, whole-genome analysis found this strain was closer to H. haemolyticus. Phylogenetic and mass spectrometry analyses indicated that strain 2019-19 was in the same cluster as H. haemolyticus. Comparison of quinolone resistance-determining regions showed strain 2019-19 possessed various amino acid substitutions, including those associated with quinolone resistance. This report highlights the existence of high-level quinolone-resistant Haemophilus species that have been isolated from both adults and children.

引用

页码：104 / 110

页数：7

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