Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications

被引：36
|
作者：
Zhang, Xin [1 ,2 ]
Yao, Meinan [1 ,2 ]
Chen, Muhua [1 ,2 ]
Li, Liqiang [1 ,2 ]
Dong, Chengyan [3 ]
Hou, Yi [4 ]
Zhao, Huiyun [1 ,2 ,5 ]
Jia, Bing [1 ,2 ,5 ]
Wang, Fan [1 ,2 ,3 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Med Isotopes Res Ctr, Sch Basic Med Sci, Beijing 100191, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Dept Radiat Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
[3] Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China
[4] Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
[5] Peking Univ, Med & Hlth Analyt Ctr, Beijing 100191, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 39期
基金：
中国国家自然科学基金;
关键词：
HA-Ag NPs; long-term stability; low cytotoxicity; nanoplatform; X-ray computed tomography (CT); SPECT imaging; RAY COMPUTED-TOMOGRAPHY; GOLD NANOPARTICLES; TOXICITY; SULFIDATION; AGENTS; CELLS;
D O I：
10.1021/acsami.6b08166
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
An efficient chemical reduction protocol has been developed for the synthesis of hyaluronic acid-coated silver nanoparticles (HA-Ag NPs) that are spherical, ultrasmall and monodisperse. The as-synthesized HA-Ag NPs not only exhibited excellent long-term stability and low cytotoxicity but also could be used as a nanoplatform for X-ray computed tomography (CT) and single-photon emission computed tomography (SPECT) imaging after being radiolabeled with Tc-99m.
引用
收藏
页码：25650 / 25653
页数：4
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