Synthesis of some trifluoromethyl substituted 1-methylpyrazoles

被引：11

作者：

Pavlik, JW ^{[1
]}

Ayudhya, TIN

Tantayanon, S

机构：

[1] Worcester Polytech Inst, Dept Chem & Biochem, Worcester, MA 01609 USA

[2] Chulalongkorn Univ, Dept Chem, Bangkok 10330, Thailand

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 40卷 / 06期

关键词：

D O I：

10.1002/jhet.5570400619

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The major products from the reaction of beta-alkoxyvinyl trifluoromethyl ketones la-c with methylhydrazine (2) in absolute ethanol are the 3-(trifluoromethyl)-substituted-1-methylpyrazoles 3a-3c with lesser amounts of the 5-(trifluoromethyl)-substituted products 4a-4c and 5a-5c. Carrying out the reaction in non-polar, aprotic solvents can further enhance the regioselectivity favoring the 3-(trifluoromethyl)-substituted isomers.

引用

页码：1087 / 1089

页数：3