Human mesenchymal stem cells

被引：30

作者：

Chen, Xiaoyong ^{[1
]}

Huang, Jing ^{[1
]}

Wu, Jun ^{[2
,3
,4
,5
]}

Hao, Jie ^{[2
,3
,4
,5
]}

Fu, Boqiang ^{[2
,6
]}

Wang, Ying ^{[7
]}

Zhou, Bo ^{[2
,8
]}

Na, Tao ^{[9
]}

Wei, Jun ^{[2
,10
]}

Zhang, Yong ^{[2
,11
]}

Li, Qiyuan ^{[2
,12
]}

Hu, Shijun ^{[2
,13
,14
]}

Zhou, Jiaxi ^{[2
,15
]}

Yu, Junying ^{[2
,16
]}

Wu, Zhaohui ^{[17
]}

Zhu, Huanxin ^{[2
,3
,4
,5
]}

Cao, Jiani ^{[2
,3
,4
,5
]}

Wang, Lei ^{[2
,3
,4
,5
]}

Peng, Yaojin ^{[2
,3
,4
,5
]}

Liang, Lingmin ^{[2
,3
,4
,5
]}

Ma, Aijin ^{[2
,18
]}

Zhang, Yu ^{[2
,10
]}

Zhao, Tongbiao ^{[2
,3
,4
,5
]}

Xiang, Andy Peng ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Key Lab Stem Cells & Tissue Engn, Minist Educ, Ctr Stem Cell Biol & Tissue Engn, Guangzhou, Peoples R China

[2] Chinese Soc Stem Cell Res, Shanghai, Peoples R China

[3] Chinese Acad Sci, Inst Zool, Inst Stem Cell & Regenerat, Natl Stem Cell Resource Ctr,State Key Lab Stem Ce, Beijing, Peoples R China

[4] Univ Chinese Acad Sci, Beijing, Peoples R China

[5] Beijing Inst Stem Cell & Regenerat Med, Beijing, Peoples R China

[6] China Natl Inst Metrol, Beijing, Peoples R China

[7] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China

[8] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China

[9] Natl Inst Food & Drug Control, Beijing, Peoples R China

[10] Zephyrm Biotechnol Co Ltd, Beijing, Peoples R China

[11] HHLIFE Co Inc Shenzhen, Shenzhen, Peoples R China

[12] China Natl GeneBank, Shenzhen, Peoples R China

[13] Soochow Univ, Med Coll, Affiliated Hosp 1, Dept Cardiovasc Surg, Suzhou, Peoples R China

[14] Soochow Univ, Med Coll, Inst Cardiovasc Sci, Collaborat Innovat Ctr Hematol,State Key Lab Radi, Suzhou, Peoples R China

[15] Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Tianjin, Peoples R China

[16] Nuwacell Biotechnol Co Ltd, Hefei, Peoples R China

[17] China Med Biotech Assoc, Beijing, Peoples R China

[18] Beijing Technol & Business Univ, Beijing, Peoples R China

来源：

CELL PROLIFERATION | 2022年 / 55卷 / 04期

基金：

中国国家自然科学基金;

关键词：

BONE-MARROW; HETEROGENEITY;

D O I：

10.1111/cpr.13141

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self-renewal capacity, multipotency and potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle to limit their translation into practice, as cells from different tissue sources or each individual have great differences in their transcriptomic signatures, differentiation potential and biological functions. Therefore, there is an urgent need for consensus standard for the quality control and technical specifications of MSCs. 'Human Mesenchymal Stem Cells' is the latest set of guidelines on hMSC in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, test regulations, instructions for use, labelling requirements, packaging requirements, storage requirements, transportation requirements and waste disposal requirements for hMSC, which is applicable to the quality control for hMSC. It was originally released by the China Society for Cell Biology on 9 January 2021. We hope that publication of these guidelines will facilitate institutional establishment, acceptance and execution of proper protocols, and accelerate the international standardization of hMSC for clinical development and therapeutic applications.

引用

页数：11

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