Five newly identified HLA alleles: A*0310, A*2907, B*4435, Cw*0206, Cw*0506, and confirmation of A*3106, B*3924, Cw*0314, DRB1*0322, and DRB1*1433 alleles

被引：7
作者：
Anholts, JDH [1 ]
Drabbels, J [1 ]
Verduijn, W [1 ]
Oudshoorn, M [1 ]
Schreuder, GMT [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands
来源：
TISSUE ANTIGENS | 2004年 / 63卷 / 01期
关键词：
HLA-A*0310; A*2907; A*3106; B*3924; B*4435; Cw*0206; Cw*0314; Cw*0506; DRB1*0322; DRB1*1433; HLA sequencing; HLA serology; PCR-SBT;
D O I：
10.1111/j.1399-0039.2004.00146.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A number of HLA alleles have been newly identified. This concerns HLA-A*0310, A*2907, B*4435, Cw*0206, Cw*0506, of which Cw*0206 was found in three unrelated individuals, all B*4002 positive. Some other alleles are also presented but confirm earlier detected sequences: A*3106, Cw*0314, DRB1*0322, and DRB1*1433. Moreover, we identified B*3924 in a bone marrow transplant recipient and in five of six unrelated stem cell donors, selected for this patient. In all cases, B*3924 was found on a haplotype combining A*0201, B*3924, Cw*0701, and DRB1*1303. The observation of this extended haplotype is of importance for the selection for stem cell transplantation. Cells expressing B*3924 and B*4435 were typed by serology as B39 and B44, respectively. Cells expressing HLA-A*0310 do not express A3 but type as A-Blank.
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收藏
页码：80 / 84
页数：5
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