MicroRNAs in Lymphoma: Regulatory Role and Biomarker Potential

被引：24

作者：

Fernandez-Mercado, Marta ^{[1
]}

Manterola, Lorea ^{[1
]}

Lawrie, Charles H. ^{[1
,2
,3
]}

机构：

[1] Biodonostia Res Inst, Oncol Area, San Sebastian, Spain

[2] Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England

[3] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

来源：

CURRENT GENOMICS | 2015年 / 16卷 / 05期

关键词：

Biomarker; Hematological malignancies; Lymphoid; Lymphoma; microRNA; ncRNA; B-CELL LYMPHOMA; NF-KAPPA-B; INDUCED CYTIDINE DEAMINASE; DOWN-REGULATION; EXPRESSION PROFILE; MIRNA EXPRESSION; MULTIPLE-MYELOMA; HODGKIN-LYMPHOMA; MYC; REVEALS;

D O I：

10.2174/1389202916666150707160147

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although it is now evident that microRNAs (miRNAs) play a critical regulatory role in many, if not all, pathological and physiological processes, remarkably they have only formally been recognized for less than fifteen years. These endogenously produced short non-coding RNAs have created a new paradigm of gene control and have utility as both novel biomarkers of cancer and as potential therapeutics. In this review we consider the role of miRNAs in lymphoid biology both under physiological (i.e. lymphopoiesis) and malignant (i.e. lymphomagenesis) conditions. In addition to the functional significance of aberrant miRNA expression in lymphomas we discuss their use as novel biomarkers, both as a in situ tumour biomarker and as a non-invasive surrogate for the tumour by testing miRNAs in the blood of patients. Finally we consider the use of these molecules as potential therapeutic agents for lymphoma (and other cancer) patients and discuss some of the hurdles yet to be overcome in order to translate this potential into clinical practice.

引用

页码：349 / 358

页数：10

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