Shelterin and the replisome: at the intersection of telomere repair and replication

被引：25

作者：

Cicconi, Alessandro ^{[1
]}

Chang, Sandy ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Lab Med, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pathol, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Biophys & Biochem, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2020年 / 60卷

关键词：

DNA-DAMAGE RESPONSE; END RESECTION; HOMOLOGOUS RECOMBINATION; GENOME INSTABILITY; ATR; PATHWAYS; TRF1; NHEJ; PROTECTION; CLASPIN;

D O I：

10.1016/j.gde.2020.02.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeres are G-rich repetitive sequences that are difficult to replicate, resulting in increased replication stress that can threaten genome stability. Shelterin protects telomeres from engaging in aberrant DNA repair and dictates the choice of DNA repair pathway at dysfunctional telomeres. Recently, shelterin has been shown to participate in telomere replication. Here we review the most recent discoveries documenting the mechanisms by which shelterin represses DNA repair pathways at telomeres while assisting its replication. The interplay between shelterin and the replisome complex highlights a novel connection between telomere maintenance and repair.

引用

页码：77 / 84

页数：8

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