Shelterin and the replisome: at the intersection of telomere repair and replication

被引：25

作者：

Cicconi, Alessandro ^{[1
]}

Chang, Sandy ^{[1
,2
,3
]}

机构：

[1] Yale Univ, Dept Lab Med, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

[2] Yale Univ, Dept Pathol, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

[3] Yale Univ, Dept Mol Biophys & Biochem, Sch Med, 330 Cedar St, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2020年 / 60卷

关键词：

DNA-DAMAGE RESPONSE; END RESECTION; HOMOLOGOUS RECOMBINATION; GENOME INSTABILITY; ATR; PATHWAYS; TRF1; NHEJ; PROTECTION; CLASPIN;

D O I：

10.1016/j.gde.2020.02.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeres are G-rich repetitive sequences that are difficult to replicate, resulting in increased replication stress that can threaten genome stability. Shelterin protects telomeres from engaging in aberrant DNA repair and dictates the choice of DNA repair pathway at dysfunctional telomeres. Recently, shelterin has been shown to participate in telomere replication. Here we review the most recent discoveries documenting the mechanisms by which shelterin represses DNA repair pathways at telomeres while assisting its replication. The interplay between shelterin and the replisome complex highlights a novel connection between telomere maintenance and repair.

引用

页码：77 / 84

页数：8

共 76 条

[11] A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms [J].

Chen, Yong ;

Rai, Rekha ;

Zhou, Zi-Ren ;

Kanoh, Junko ;

Ribeyre, Cyril ;

Yang, Yuting ;

Zheng, Hong ;

Damay, Pascal ;

Wang, Feng ;

Tsujii, Hisayo ;

Hiraoka, Yasushi ;

Shore, David ;

Hu, Hong-Yu ;

Chang, Sandy ;

Lei, Ming .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (02) :213-U282

[12] The DNA Damage Response: Making It Safe to Play with Knives [J].

Ciccia, Alberto ;

Elledge, Stephen J. .

MOLECULAR CELL, 2010, 40 (02) :179-204

[13] ATR: an essential regulator of genome integrity [J].

Cimprich, Karlene A. ;

Cortez, David .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (08) :616-627

[14] ATR and ATRIP: Partners in checkpoint signaling [J].

Cortez, D ;

Guntuku, S ;

Qin, J ;

Elledge, SJ .

SCIENCE, 2001, 294 (5547) :1713-1716

[15] Shelterin-Mediated Telomere Protection [J].

de Lange, Titia .

ANNUAL REVIEW OF GENETICS, VOL 52, 2018, 52 :223-247

[16] Multiple roles for MRE11 at uncapped telomeres [J].

Deng, Yibin ;

Guo, Xiaolan ;

Ferguson, David O. ;

Chang, Sandy .

NATURE, 2009, 460 (7257) :914-U157

[17] Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells [J].

Dev, Harveer ;

Chiang, Ting-Wei Will ;

Lescale, Chloe ;

de Krijger, Inge ;

Martin, Alistair G. ;

Pilger, Domenic ;

Coates, Julia ;

Sczaniecka-Clift, Matylda ;

Wei, Wenming ;

Ostermaier, Matthias ;

Herzog, Mareike ;

Lam, Jonathan ;

Shea, Abigail ;

Demir, Mukerrem ;

Wu, Qian ;

Yang, Fengtang ;

Fu, Beiyuan ;

Lai, Zhongwu ;

Balmus, Gabriel ;

Belotserkovskaya, Rimma ;

Serra, Violeta ;

O'Connor, Mark J. ;

Bruna, Alejandra ;

Beli, Petra ;

Pellegrini, Luca ;

Caldas, Carlos ;

Deriano, Ludovic ;

Jacobs, Jacqueline J. L. ;

Galanty, Yaron ;

Jackson, Stephen P. .

NATURE CELL BIOLOGY, 2018, 20 (08) :954-+

[18] Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching [J].

Di Virgilio, Michela ;

Callen, Elsa ;

Yamane, Arito ;

Zhang, Wenzhu ;

Jankovic, Mila ;

Gitlin, Alexander D. ;

Feldhahn, Niklas ;

Resch, Wolfgang ;

Oliveira, Thiago Y. ;

Chait, Brian T. ;

Nussenzweig, Andre ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Nussenzweig, Michel C. .

SCIENCE, 2013, 339 (6120) :711-715

[19] Shelterin complex and associated factors at human telomeres [J].

Diotti, Raffaella ;

Loayza, Diego .

NUCLEUS, 2011, 2 (02) :119-135

[20] A means to a DNA end: The many roles of Ku [J].

Downs, JA ;

Jackson, SP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (05) :367-378

← 1 2 3 4 5 6 7 8 →