Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties

被引：56

作者：

Amri, Bedis ^{[1
]}

Martino, Emanuela ^{[2
,3
]}

Vitulo, Francesca ^{[4
]}

Corana, Federica ^{[5
]}

Ben-Kaab, Leila B. ^{[1
]}

Rui, Marta ^{[6
]}

Rossi, Daniela ^{[6
]}

Mori, Michela ^{[6
]}

Rossi, Silvia ^{[3
,6
]}

Collina, Simona ^{[3
,6
]}

机构：

[1] Fac Sci Tunis El Manar, Dept Biol, Unite Rech Nutr & Metab Azote & Prot Stress UR 09, Tunis 1002, Tunisia

[2] Univ Pavia, Dept Earth & Environm Sci, Via S Epifanio 14, I-27100 Pavia, Italy

[3] Univ Pavia, CHT, Viale Taramelli 12, I-27100 Pavia, Italy

[4] Indena SpA, Via Don Minzoni 6, I-20090 Settala, Italy

[5] Univ Pavia, CGS, Via Bassi 21, I-27100 Pavia, Italy

[6] Univ Pavia, Med Chem Sect, Dept Drug Sci, Viale Taramelli 12, I-27100 Pavia, Italy

来源：

MOLECULES | 2017年 / 22卷 / 11期

关键词：

wound healing; Marrubium vulgare L; leave extract; q-NMR; antioxidant properties; HPLC-UV; PAD MS analysis; LABDANE DITERPENOIDS; NMR; IDENTIFICATION; ANTIBACTERIAL; REPAIR; MS;

D O I：

10.3390/molecules22111851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatographyultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated.

引用

页数：18

共 59 条

[1] Phytochemical profiling, in vitro evaluation of total phenolic contents and antioxidant properties of Marrubium vulgare (horehound) leaves of plants growing in Algeria [J].