An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn

被引：33

作者：

Abarca, Belen ^{[1
]}

Adam, Rosa ^{[1
]}

Ballesteros, Rafael ^{[1
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 09期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; CATALYTIC TRANSFER HYDROGENATION; TRANSITION-METAL; UNSYMMETRICAL SECONDARY; BORROWING HYDROGEN; TERTIARY-AMINES; REDUCTION; WATER; RUTHENIUM; ZINC;

D O I：

10.1039/c1ob05888f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N-alkylating agents in a hydrogen autotransfer process. 1,2,3,4-Tetrahydroquinolines and N-alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.

引用

页码：1826 / 1833

页数：8

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