Telomere Biology and Thoracic Aortic Aneurysm

被引：15

作者：

Aschacher, Thomas ^{[1
]}

Salameh, Olivia ^{[2
]}

Enzmann, Florian ^{[3
]}

Messner, Barbara ^{[1
]}

Bergmann, Michael ^{[4
,5
]}

机构：

[1] Med Univ Vienna, Dept Surg, Cardiac Surg Res Lab, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Surg, Plast & Reconstruct Surg, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[3] Paracelsius Med Univ, Dept Vasc & Endovasc Surg, Muellner Hauptstr 48, A-5020 Salzburg, Austria

[4] Med Univ Vienna, Dept Surg, Surg Res Labs, Waehringer Guertel 18-20, A-1090 Vienna, Austria

[5] Comprehens Canc Ctr, A-1090 Vienna, Austria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 01期

关键词：

telomeres; telomere maintenance mechanism; telomerase; aging; aortic aneurysm; FIBROBLAST GROWTH FACTOR-2; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; REVERSE-TRANSCRIPTASE; ENDOTHELIAL-CELLS; DNA-DAMAGE; CELLULAR SENESCENCE; IMMORTAL CELLS; LENGTH; DISEASE;

D O I：

10.3390/ijms19010003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ascending aortic aneurysms are mostly asymptomatic and present a great risk of aortic dissection or perforation. Consequently, ascending aortic aneurysms are a source of lethality with increased age. Biological aging results in progressive attrition of telomeres, which are the repetitive DNA sequences at the end of chromosomes. These telomeres play an important role in protection of genomic DNA from end-to-end fusions. Telomere maintenance and telomere attrition-associated senescence of endothelial and smooth muscle cells have been indicated to be part of the pathogenesis of degenerative vascular diseases. This systematic review provides an overview of telomeres, telomere-associated proteins and telomerase to the formation and progression of aneurysms of the thoracic ascending aorta. A better understanding of telomere regulation in the vascular pathology might provide new therapeutic approaches. Measurements of telomere length and telomerase activity could be potential prognostic biomarkers for increased risk of death in elderly patients suffering from an aortic aneurysm.

引用

页数：16

共 132 条

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