Development of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

被引：16

作者：

Farr, Grant ^{[1
]}

Shah, Keyur ^{[2
]}

Markley, Roshi ^{[2
]}

Abbate, Antonio ^{[2
]}

Salloum, Fadi N. ^{[3
]}

Grinnan, Dan ^{[1
]}

机构：

[1] Virginia Commonwealth Univ Hlth Syst, Div Pulm & Crit Care Med, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ Hlth Syst, VCU Pauley Heart Ctr, Richmond, VA USA

[3] Virginia Commonwealth Univ Hlth Syst, Victoria Johnson Res Labs, Richmond, VA USA

来源：

PROGRESS IN CARDIOVASCULAR DISEASES | 2016年 / 59卷 / 01期

关键词：

Pulmonary hypertension; Heart failure; Diastolic dysfunction; CAPILLARY WEDGE PRESSURE; OBSTRUCTIVE SLEEP-APNEA; ARTERIAL-HYPERTENSION; VENTILATORY EFFICIENCY; EUROPEAN-SOCIETY; VENOUS-PRESSURE; HIGH PREVALENCE; POTENTIAL ROLE; TASK-FORCE; EXERCISE;

D O I：

10.1016/j.pcad.2016.06.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary hypertension (PH) is common in patients with heart failure with preserved ejection fraction (HFpEF). While PH-HFpEF may affect more than a million patients in the United States alone, it has been difficult to study its epidemiology and response to treatment due to difficulty in properly defining the illness. While chronic remodeling of the pulmonary vasculature is related to chronic passive congestion of the pulmonary circulation from the pulmonary veins, there are likely other contributors to the development of PH-HFpEF. We explore the potential direct contributions of obesity, diabetes mellitus, genetics, and sleep apnea on the pulmonary circulation in those with PH-HFpEF, and we discuss the potential role of exercise testing or fluid challenge during diagnostic testing. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：52 / 58

页数：7

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