Primary pancreatic lymphoma: Clinical presentation, diagnosis, treatment, and outcome

被引：26

作者：

Facchinelli, Davide ^{[1
]}

Sina, Sokol ^{[2
]}

Boninsegna, Enrico ^{[3
]}

Borin, Alex ^{[4
]}

Tisi, Maria C. ^{[5
]}

Piazza, Francesco ^{[6
]}

Scapinello, Greta ^{[6
]}

Maiolo, Elena ^{[7
]}

Hohaus, Stefan ^{[7
]}

Zamo, Alberto ^{[8
]}

Merli, Michele ^{[9
]}

Stefani, Piero M. ^{[10
]}

Mellone, Federica ^{[11
]}

Basso, Marco ^{[12
]}

Sartori, Roberto ^{[12
]}

Rusconi, Chiara ^{[13
]}

Parisi, Alice ^{[2
]}

Manfrin, Erminia ^{[2
]}

Krampera, Mauro ^{[1
]}

Ruggeri, Marco ^{[5
]}

Visco, Carlo ^{[1
]}

Tecchio, Cristina ^{[1
]}

机构：

[1] Univ Verona, Dept Med, Hematol Unit, Verona, Italy

[2] Univ Verona, Dept Diagnost & Publ Hlth, Verona, Italy

[3] ASST, Dept Radiol, Mantua, Italy

[4] Univ Verona, Pancreas Inst, Dept Surg & Oncol, Unit Gen & Pancreat Surg, Verona, Italy

[5] Osped San Bortolo, Hematol Unit, Viale Ferdinando Rodolfi 37, I-36100 Vicenza, Italy

[6] Univ Padua, Dept Med, Hematol Unit, Padua, Italy

[7] Univ Cattolica Sacro Cuore, Ist Ematol, Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy

[8] AOU Citta Salute & Sci, Dept Oncol & Pathol Unit, Turin, Italy

[9] Univ Insubria, Osped Circolo & Fdn Macchi ASST Sette Laghi, Div Hematol, Varese, Italy

[10] Osped Ca Foncello, Hematol Unit, Treviso, Italy

[11] Univ Verona, Inst Med Stat, Verona, Italy

[12] Osped Casteifranco Veneto, Hematol Unit, Vicenza, Italy

[13] ASST Niguarda Hosp, Div Hematol, Milan, Italy

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2020年 / 105卷 / 04期

关键词：

chemotherapy; lymphoma; pancreas; surgery; HODGKINS-LYMPHOMA; CELL LYMPHOMA;

D O I：

10.1111/ejh.13468

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. Objectives To describe PPL clinical, diagnostic and histological characteristics, together with therapy and outcome, in a relatively large series of patients. Methods The study includes 39 PPL patients, aged >= 15 years, observed from January 2005 to December 2018, in 8 Italian Institutions. Results The main symptoms were abdominal pain (58%) and jaundice (47%). Lactate dehydrogenase serum levels were elevated in 43% of patients. Histological specimens were mostly obtained by percutaneous (41%) or endoscopic (36%) biopsy, with diffuse large B-cell lymphoma being the most frequent (69%) histological diagnosis. Chemotherapy was administered alone in 65% of patients, with radiotherapy in 17%, or after surgery in 9%. The 2-year overall survival (OS) was 62%, the 2-year progression-free survival (PFS) 44%. Debulking surgery (with or without chemotherapy) was associated with a significant worse OS. Three (9.4%) of 32 high-grade patients experienced a central nervous system (CNS) relapse. Conclusions PPL is rare, often high-grade, with symptoms and localization similar to other pancreatic malignancies. Biopsy should be the preferred diagnostic method. High-grade PPL should undergo CNS prophylaxis.

引用

页码：468 / 475

页数：8

共 26 条

[1]

Arcari A, 2005, HAEMATOLOGICA, V90, pECR09

[2]

BAYLOR S M, 1973, Journal of Surgical Oncology, V5, P335, DOI 10.1002/jso.2930050410

[3] PANCREATIC LYMPHOMA - IS IT A SURGICAL DISEASE [J].