Transient Receptor Potential A1 Modulators

被引：9

作者：

Strassmaier, Tim ^{[1
]}

Bakthavatchalam, Rajagopal ^{[1
]}

机构：

[1] Hydra Biosci, Cambridge, MA 02139 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 17期

关键词：

Transient receptor potential; TRP channel; TRPA1; pain; asthma; inflammatory; ION-CHANNEL TRPA1; SENSORY NEURONS; NEUROGENIC INFLAMMATION; NOCICEPTIVE NEURONS; IN-VITRO; C-FIBERS; COLD; ACTIVATION; CONTRIBUTES; ANTAGONIST;

D O I：

10.2174/156802611796904915

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.

引用

收藏

页码：2227 / 2236

页数：10

相关论文

共 69 条

[1]

ABBOT LAB, 2009, Patent No. 2009089082

[2] Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress [J].

Andersson, David A. ;

Gentry, Clive ;

Moss, Sian ;

Bevan, Stuart .

JOURNAL OF NEUROSCIENCE, 2008, 28 (10) :2485-2494

[3] Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids [J].

Andersson, David A. ;

Nash, Mark ;

Bevan, Stuart .

JOURNAL OF NEUROSCIENCE, 2007, 27 (12) :3347-3355

[4] Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents [J].

Andre, E. ;

Gatti, R. ;

Trevisani, M. ;

Preti, D. ;

Baraldi, P. G. ;

Patacchini, R. ;

Geppetti, P. .

BRITISH JOURNAL OF PHARMACOLOGY, 2009, 158 (06) :1621-1628

[5] Cigarette smoke-induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents [J].

Andre, Eunice ;

Campi, Barbara ;

Materazzi, Serena ;

Trevisani, Marcello ;

Amadesi, Silvia ;

Massi, Daniela ;

Creminon, Christophe ;

Vaksman, Natalya ;

Nassini, Romina ;

Civelli, Maurizio ;

Baraldi, Pier Giovanni ;

Poole, Daniel P. ;

Bunnett, Nigel W. ;

Geppetti, Pierangelo ;

Patacchini, Riccardo .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (07) :2574-2582

[6] Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin [J].

Bandell, M ;

Story, GM ;

Hwang, SW ;

Viswanath, V ;

Eid, SR ;

Petrus, MJ ;

Earley, TJ ;

Patapoutian, A .

NEURON, 2004, 41 (06) :849-857

[7] Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens [J].

Bassoli, Angela ;

Borgonova, Gigliola ;

Caimi, Sara ;

Scaglioni, Leonardo ;

Morini, Gabriella ;

Moriello, Aniello Schiano ;

Di Marzo, Vincenzo ;

De Petrocellis, Luciano .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (04) :1636-1639

[8] TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents [J].

Bautista, DM ;

Jordt, SE ;

Nikai, T ;

Tsuruda, PR ;

Read, AJ ;

Poblete, J ;

Yamoah, EN ;

Basbaum, AI ;

Julius, D .

CELL, 2006, 124 (06) :1269-1282

[9] TRPA1 is a major oxidant sensor in murine airway sensory neurons [J].

Bessac, Bret F. ;

Sivula, Michael ;

Von Hehn, Christian A. ;

Escalera, Jasmine ;

Cohn, Lauren ;

Jordt, Sven-Eric .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (05) :1899-1910

[10] Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases [J].

Bessac, Bret F. ;

Sivula, Michael ;

von Hehn, Christian A. ;

Caceres, Ana I. ;

Escalera, Jasmine ;

Jordt, Sven-Eric .

FASEB JOURNAL, 2009, 23 (04) :1102-1114

← 1 2 3 4 5 6 7 →