Late graft rejection and second infusion of bone marrow in children with aplastic anaemia

被引：16

作者：

Eapen, M

Davies, SM

Ramsay, NKC

机构：

[1] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 104卷 / 01期

关键词：

SAA; late graft rejection; second transplant;

D O I：

10.1046/j.1365-2141.1999.01159.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Late graft rejection following allogeneic bone marrow transplantation (BMT) for aplastic anaemia is a significant clinical problem and is associated with a high risk of mortality. We report two children with severe aplastic anaemia (SAA) who developed very late graft rejection 2 years and 4 months and 10 years respectively after allogeneic BMT from HLA-identical siblings. Following a second BMT from their initial donors, engraftment has been sustained in both cases, The patients are alive with full donor chimaerism, 18 and 19 years from initial transplant. These cases illustrate that graft failure can be an extremely late event after allogeneic BMT for SAA, and that long-term sustained engraftment can be achieved in these patients with second BMT from the original donors.

引用

页码：186 / 188

页数：3