Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium vivax Malaria

被引：40

作者：

Rijken, Marcus J. ^{[1
]}

McGready, Rose ^{[1
,2
,3
]}

Jullien, Vincent ^{[4
,5
]}

Tarning, Joel ^{[2
,3
]}

Lindegardh, Niklas ^{[2
,3
]}

Phyo, Aung Pyae ^{[1
]}

Win, Aye Kyi ^{[1
]}

Hsi, Poe ^{[1
]}

Cammas, Mireille ^{[4
,5
]}

Singhasivanon, Pratap

White, Nicholas J. ^{[2
,3
]}

Nosten, Francois ^{[1
,2
,3
]}

机构：

[1] Shoklo Malaria Res Unit, Mae Sot 63110, Tak, Thailand

[2] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok 10400, Thailand

[3] Univ Oxford, Ctr Clin Vaccinol & Trop Med, Nuffield Dept Clin Med, Oxford OX3 7LJ, England

[4] Univ Paris 05, Assistance Publ Hop Paris, INSERM, U663, Paris, France

[5] Hop St Vincent de Paul, F-75674 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期

基金：

英国惠康基金;

关键词：

UNCOMPLICATED FALCIPARUM-MALARIA; POPULATION PHARMACOKINETICS; SULFADOXINE-PYRIMETHAMINE; ANTIMALARIAL-DRUGS; RANDOMIZED-TRIAL; ARTESUNATE; TOLERABILITY; CHLOROQUINE; COMBINATION; SAFETY;

D O I：

10.1128/AAC.00154-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and with Plasmodium vivax malaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data were evaluated using noncompartmental analysis. There were no clinically relevant differences in the pharmacokinetics of amodiaquine and desethylamodiaquine between pregnant (n = 24) and postpartum (n = 18) women. The results suggest that the current amodiaquine dosing regimen is adequate for the treatment of P. vivax infections during pregnancy.

引用

页码：4338 / 4342

页数：5

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