Effects of Genistein, Apigenin, Quercetin, Rutin and Astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice

被引：86

作者：

Huang, Jingqun ^{[1
]}

Wang, Siwang ^{[2
]}

Zhu, Miaozhang ^{[1
]}

Chen, Jianzong ^{[3
]}

Zhu, Xiaoxing ^{[4
]}

机构：

[1] Fourth Mil Med Univ, Sch Basic Med, Dept Physiol, Xian 710032, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Sch Pharm, Inst Mat, Xian 710032, Shaanxi, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Shaanxi, Peoples R China

[4] Fourth Mil Med Univ, Xijing Hosp, Dept Ultrasound, Xian 710032, Shaanxi, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2011年 / 49卷 / 09期

关键词：

Genistein; Apigenin; Quercetin; Rutin; Astilbin; Xanthine oxidase; METABOLIC SYNDROME; FLAVONOIDS; OXONATE; DISEASE; GOUT; DEHYDROGENASE; HYPERTENSION; INHIBITION; TOXICITY; LIVER;

D O I：

10.1016/j.fct.2011.04.029

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Flavonoids are widely found in plants and many of them possess biological and pharmacological activities. In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and in serum and the liver. The effects of the flavonoids on serum uric acid levels were also measured in vivo. In vitro studies indicated that the flavonoids tested did not significantly affect XO activity. However, significant increases and decreases in XO activities were observed in vivo. Moreover, serum XO activity was correlated with serum uric acid levels, while no correlation was observed for liver XO activity. The present study showed that serum uric acid levels in mice treated with the flavonoids tested here are higher than control levels. Therefore, the flavonoids tested here are not candidates for replacing Allopurinol as a treatment to reduce serum uric acid levels. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1943 / 1947

页数：5

共 25 条

[1] Determination of xanthine oxidase in human serum by a competitive enzyme-linked immunosorbent assay (ELISA) [J].

Battelli, MG ;

Abbondanza, A ;

Musiani, S ;

Buonamici, L ;

Strocchi, P ;

Tazzari, PL ;

Gramantieri, L ;

Stirpe, F .

CLINICA CHIMICA ACTA, 1999, 281 (1-2) :147-158

[2]

CARROLL JJ, 1971, CLIN CHEM, V17, P158

[3] Prevalence of the metabolic syndrome in individuals with hyperuricemia [J].

Choi, Hyon K. ;

Ford, Earl S. .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (05) :442-447

[4]

FINCO DR, 1976, J AM VET MED ASSOC, V168, P593

[5] SUBSTITUTED CYCLIC IMIDES AS POTENTIAL ANTIGOUT AGENTS [J].

HALL, IH ;

SCOVILLE, JP ;

REYNOLDS, DJ ;

SIMLOT, R ;

DUNCAN, P .

LIFE SCIENCES, 1990, 46 (26) :1923-1927

[6] Role of uric acid in hypertension, renal disease, and metabolic syndrome [J].

Heinig, Marcelo ;

Johnson, Richard J. .

CLEVELAND CLINIC JOURNAL OF MEDICINE, 2006, 73 (12) :1059-1064

[7] A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice [J].

Kong, LD ;

Yang, C ;

Ge, F ;

Wang, HD ;

Guo, YS .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 93 (2-3) :325-330

[8] Molecular modeling of flavonoids that inhibits xanthine oxidase [J].

Lin, CM ;

Chen, CS ;

Chen, CT ;

Liang, YC ;

Lin, JK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 294 (01) :167-172

[9] Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon? [J].

Lotito, Silvina B. ;

Frei, Balz .

FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (12) :1727-1746

[10] Hypouricemic action of selected flavonoids in mice: Structure-activity relationships [J].

Mo, Shi-Fu ;

Zhou, Feng ;

Lv, Yao-Zhong ;

Hu, Qing-Hua ;

Zang, Dong-Mei ;

Kong, Ling-Dong .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2007, 30 (08) :1551-1556

← 1 2 3 →